Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson’s disease

The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a defining pathological hallmark of Parkinson’s disease (PD). Nevertheless, the molecular features associated with DA neuron vulnerability have not yet been fully identified. Here, we developed a protocol to enrich...

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Detalles Bibliográficos
Autores principales: Kamath, Tushar, Abdulraouf, Abdulraouf, Burris, S. J., Langlieb, Jonah, Gazestani, Vahid, Nadaf, Naeem M., Balderrama, Karol, Vanderburg, Charles, Macosko, Evan Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076534/
https://www.ncbi.nlm.nih.gov/pubmed/35513515
http://dx.doi.org/10.1038/s41593-022-01061-1

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