Identification, optimization, and biological evaluation of 3-O-β-chacotriosyl ursolic acid derivatives as novel SARS-CoV-2 entry inhibitors by targeting the prefusion state of spike protein

The COVID-19 pandemic generates a global threat to public health and continuously emerging SARS-CoV-2 variants bring a great challenge to the development of both vaccines and antiviral agents. In this study, we identified UA-18 and its optimized analog UA-30 via the hit-to-lead strategy as novel SAR...

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Detalles Bibliográficos
Autores principales: Li, Hui, Cheng, Chen, Shi, Shanshan, Wu, Yan, Gao, Yongfeng, Liu, Zhihao, Liu, Mingjian, Li, Zhaodong, Huo, Lijian, Pan, Xiaoyan, Liu, Shuwen, Song, Gaopeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076589/
https://www.ncbi.nlm.nih.gov/pubmed/35551037
http://dx.doi.org/10.1016/j.ejmech.2022.114426

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