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BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis

Age-related osteoporosis is characterized by the accumulation of senescent osteoblastic cells in bone microenvironment and significantly reduced osteogenic differentiation. Clearing of the senescent cells is helpful to improve bone formation in aged mice. Bone morphogenetic protein 9 (BMP9), a multi...

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Detalles Bibliográficos
Autores principales:	Xu, Jing-zun, Zhou, Yan-man, Zhang, Lin-lin, Chen, Xiao-jing, Yang, Yu-ying, Zhang, Deng, Zhu, Ke-cheng, Kong, Xiao-ke, Sun, Li-hao, Tao, Bei, Zhao, Hong-yan, Liu, Jian-min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076651/ https://www.ncbi.nlm.nih.gov/pubmed/35523787 http://dx.doi.org/10.1038/s41420-022-01048-8

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