Glutathione prevents high glucose-induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS/TGFβ/SMAD pathway

The activation of pancreatic stellate cells (PSCs) is the key mechanism of pancreatic fibrosis, which can lead to β-cell failure. Oxidative stress is an important risk factor for PSC activation. There is no direct evidence proving if administration of glutathione can inhibit fibrosis and β-cell fail...

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Detalles Bibliográficos
Autores principales: Zhang, Jitai, Bai, Juan, Zhou, Qian, Hu, Yuxin, Wang, Qian, Yang, Lanting, Chen, Huamin, An, Hui, Zhou, Chuanzan, Wang, Yongyu, Chen, Xiufang, Li, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076672/
https://www.ncbi.nlm.nih.gov/pubmed/35523788
http://dx.doi.org/10.1038/s41419-022-04894-7

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