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Tomatidine-stimulated maturation of human embryonic stem cell-derived cardiomyocytes for modeling mitochondrial dysfunction

Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) have been reported to exhibit immature embryonic or fetal cardiomyocyte-like phenotypes. To enhance the maturation of hESC-CMs, we identified a natural steroidal alkaloid, tomatidine, as a new substance that stimulates the maturation of hES...

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Detalles Bibliográficos
Autores principales:	Kim, Ye Seul, Yoon, Jung Won, Kim, Dasol, Choi, Seunghak, Kim, Hyoung Kyu, Youm, Jae Boum, Han, Jin, Heo, Soon Chul, Hyun, Sung-Ae, Seo, Jung-Wook, Kim, Deok-Ho, Kim, Jae Ho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076832/ https://www.ncbi.nlm.nih.gov/pubmed/35379934 http://dx.doi.org/10.1038/s12276-022-00746-8

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