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Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP

Protein synthesis is supported by cellular machineries that ensure polypeptides fold to their native conformation, whilst eliminating misfolded, aggregation prone species. Protein aggregation underlies pathologies including neurodegeneration. Aggregates’ formation is antagonised by molecular chapero...

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Detalles Bibliográficos
Autores principales:	Melo, Eduardo Pinho, Konno, Tasuku, Farace, Ilaria, Awadelkareem, Mosab Ali, Skov, Lise R., Teodoro, Fernando, Sancho, Teresa P., Paton, Adrienne W., Paton, James C., Fares, Matthew, Paulo, Pedro M. R., Zhang, Xin, Avezov, Edward
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076838/ https://www.ncbi.nlm.nih.gov/pubmed/35523806 http://dx.doi.org/10.1038/s41467-022-30238-2

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