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A novel non-invasive method of measuring microcirculatory perfusion and blood velocity in infants: a pilot study
Current haemodynamic monitoring is mainly aimed at the macrocirculation. Multiple studies have demonstrated the importance of the microcirculation in relation to the patient’s condition and impact of treatment strategies. However, continuous monitoring of the microcirculation is not yet possible in...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076848/ https://www.ncbi.nlm.nih.gov/pubmed/35523975 http://dx.doi.org/10.1038/s41598-022-10911-8 |
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author | Gangaram-Panday, Norani H. te Nijenhuis, Louwrina H. Fine, Ilya Reiss, Irwin K. M. van Weteringen, Willem |
author_facet | Gangaram-Panday, Norani H. te Nijenhuis, Louwrina H. Fine, Ilya Reiss, Irwin K. M. van Weteringen, Willem |
author_sort | Gangaram-Panday, Norani H. |
collection | PubMed |
description | Current haemodynamic monitoring is mainly aimed at the macrocirculation. Multiple studies have demonstrated the importance of the microcirculation in relation to the patient’s condition and impact of treatment strategies. However, continuous monitoring of the microcirculation is not yet possible in the neonatal field. A novel dynamic light scattering (DLS) sensor technology for continuous monitoring of the microcirculation was investigated in the neonatal population. Thirty-one haemodynamically stable infants were included. Sequential measurements at the forehead, upper extremity, thorax, abdomen and lower extremity were conducted with the DLS sensor. For analyses stable measurements were selected. The DLS parameters, total blood flow (TBF) and relative blood velocity (RBV), were compared between measurement locations. Changes in relative haemodynamic indices (relHIs), indicating the distribution of blood flow in the microcirculatory blood vessels, were associated with heart rate decelerations. Measurements performed at the forehead had significantly lower TBF levels, compared to measurements at other locations. Early changes in relHIs around a heart rate deceleration were recorded a median (IQR) of 22.0 (13.5–27.0) s before the onset. Measurement of the currently unavailable parameters TBF, RBV and relHIs is possible with DLS technology. Validation of the DLS technology is needed for clinical implementation. |
format | Online Article Text |
id | pubmed-9076848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90768482022-05-08 A novel non-invasive method of measuring microcirculatory perfusion and blood velocity in infants: a pilot study Gangaram-Panday, Norani H. te Nijenhuis, Louwrina H. Fine, Ilya Reiss, Irwin K. M. van Weteringen, Willem Sci Rep Article Current haemodynamic monitoring is mainly aimed at the macrocirculation. Multiple studies have demonstrated the importance of the microcirculation in relation to the patient’s condition and impact of treatment strategies. However, continuous monitoring of the microcirculation is not yet possible in the neonatal field. A novel dynamic light scattering (DLS) sensor technology for continuous monitoring of the microcirculation was investigated in the neonatal population. Thirty-one haemodynamically stable infants were included. Sequential measurements at the forehead, upper extremity, thorax, abdomen and lower extremity were conducted with the DLS sensor. For analyses stable measurements were selected. The DLS parameters, total blood flow (TBF) and relative blood velocity (RBV), were compared between measurement locations. Changes in relative haemodynamic indices (relHIs), indicating the distribution of blood flow in the microcirculatory blood vessels, were associated with heart rate decelerations. Measurements performed at the forehead had significantly lower TBF levels, compared to measurements at other locations. Early changes in relHIs around a heart rate deceleration were recorded a median (IQR) of 22.0 (13.5–27.0) s before the onset. Measurement of the currently unavailable parameters TBF, RBV and relHIs is possible with DLS technology. Validation of the DLS technology is needed for clinical implementation. Nature Publishing Group UK 2022-05-06 /pmc/articles/PMC9076848/ /pubmed/35523975 http://dx.doi.org/10.1038/s41598-022-10911-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Gangaram-Panday, Norani H. te Nijenhuis, Louwrina H. Fine, Ilya Reiss, Irwin K. M. van Weteringen, Willem A novel non-invasive method of measuring microcirculatory perfusion and blood velocity in infants: a pilot study |
title | A novel non-invasive method of measuring microcirculatory perfusion and blood velocity in infants: a pilot study |
title_full | A novel non-invasive method of measuring microcirculatory perfusion and blood velocity in infants: a pilot study |
title_fullStr | A novel non-invasive method of measuring microcirculatory perfusion and blood velocity in infants: a pilot study |
title_full_unstemmed | A novel non-invasive method of measuring microcirculatory perfusion and blood velocity in infants: a pilot study |
title_short | A novel non-invasive method of measuring microcirculatory perfusion and blood velocity in infants: a pilot study |
title_sort | novel non-invasive method of measuring microcirculatory perfusion and blood velocity in infants: a pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076848/ https://www.ncbi.nlm.nih.gov/pubmed/35523975 http://dx.doi.org/10.1038/s41598-022-10911-8 |
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