An aptamer agonist of the insulin receptor acts as a positive or negative allosteric modulator, depending on its concentration

Aptamers are widely used as binders that interact with targets with high affinity or as inhibitors of the function of target molecules. However, they have also been used to modulate target protein function, which they achieve by activating the target or stabilizing its conformation. Here, we report...

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Detalles Bibliográficos
Autores principales: Yunn, Na-Oh, Lee, Jimin, Lee, Hye Sun, Oh, Eun Ju, Park, Mangeun, Park, Seongeun, Jin, Seo Yeon, Shin, Euisu, Lee, Jo woon yi, Kim, Youndong, Bae, Sun Sik, Ryu, Sung Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076861/
https://www.ncbi.nlm.nih.gov/pubmed/35478209
http://dx.doi.org/10.1038/s12276-022-00760-w

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