Preventing erosion of X-chromosome inactivation in human embryonic stem cells

X-chromosome inactivation is a paradigm of epigenetic transcriptional regulation. Female human embryonic stem cells (hESCs) often undergo erosion of X-inactivation upon prolonged culture. Here, we investigate the sources of X-inactivation instability by deriving new primed pluripotent hESC lines. We...

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Detalles Bibliográficos
Autores principales: Cloutier, Marissa, Kumar, Surinder, Buttigieg, Emily, Keller, Laura, Lee, Brandon, Williams, Aaron, Mojica-Perez, Sandra, Erliandri, Indri, Rocha, Andre Monteiro Da, Cadigan, Kenneth, Smith, Gary D., Kalantry, Sundeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076865/
https://www.ncbi.nlm.nih.gov/pubmed/35523820
http://dx.doi.org/10.1038/s41467-022-30259-x

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