Grem1 accelerates nucleus pulposus cell apoptosis and intervertebral disc degeneration by inhibiting TGF-β-mediated Smad2/3 phosphorylation

Intervertebral disc degeneration (IVDD) is a main cause of low back pain, and inflammatory factors play key roles in its pathogenesis. Gremlin-1 (Grem1) was reported to induce an inflammatory response in other fields. This study aimed to investigate the mechanisms of Grem1 in the degenerative proces...

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Detalles Bibliográficos
Autores principales: Chen, Shunlun, Lei, Linchuan, Li, Zemin, Chen, Fan, Huang, Yuming, Jiang, Guowei, Guo, Xingyu, Zhao, Zhuoyang, Liu, Hui, Wang, Hua, Liu, Caijun, Zheng, Zhaomin, Wang, Jianru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076866/
https://www.ncbi.nlm.nih.gov/pubmed/35440754
http://dx.doi.org/10.1038/s12276-022-00753-9

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