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Autoimmune pulmonary alveolar proteinosis with features similar to nonspecific interstitial pneumonia

A 58-year-old woman with cough and dyspnea who was suspected of having idiopathic interstitial pneumonia had been treated with corticosteroids and cyclosporine, but the symptoms had worsened. There were no findings to suspect pulmonary alveolar proteinosis (PAP) in the bronchoalveolar lavage fluid,...

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Detalles Bibliográficos
Autores principales: Fujii, Koki, Takeshima, Hideyuki, Nishimura, Taku, Sakatani, Toshio, Masuda, Yoshio, Morikawa, Teppei, Usui, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076885/
https://www.ncbi.nlm.nih.gov/pubmed/35535320
http://dx.doi.org/10.1016/j.rmcr.2022.101591
Descripción
Sumario:A 58-year-old woman with cough and dyspnea who was suspected of having idiopathic interstitial pneumonia had been treated with corticosteroids and cyclosporine, but the symptoms had worsened. There were no findings to suspect pulmonary alveolar proteinosis (PAP) in the bronchoalveolar lavage fluid, 17 months after the start of treatment. The transbronchial lung biopsy specimens showed eosinophilic bodies that strongly stained with periodic acid-Schiff staining. Anti-granulocyte macrophage colony-stimulating factor (anti-GM-CSF) antibodies were detected in her serum. We diagnosed the patient with autoimmune PAP. Thus, we present a rare case of PAP presenting atypical radiological images and bronchoalveolar lavage fluid findings.