Cargando…

Structural basis for substrate discrimination by E. coli repair enzyme, AlkB

E. coli AlkB, a repair enzyme of the dioxygenase family, catalyses the removal of mutagenic methylated nucleotides from the genome. Known for substrate promiscuity, AlkB's catalytic mechanism and conformational changes accompanying substrate binding have been extensively dissected. However, the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jayanth, Namrata, Ogirala, Nirmala, Yadav, Anil, Puranik, Mrinalini
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076979/ https://www.ncbi.nlm.nih.gov/pubmed/35540905 http://dx.doi.org/10.1039/c7ra11333a

Ejemplares similares

NAIL-MS reveals the repair of 2-methylthiocytidine by AlkB in E. coli
por: Reichle, Valentin F., et al.
Publicado: (2019)

Structure and mechanism of the alkane-oxidizing enzyme AlkB
por: Guo, Xue, et al.
Publicado: (2023)

Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB
por: Kurowski, Michal A, et al.
Publicado: (2003)

DNA Damage: Quantum Mechanics/Molecular Mechanics Study on the Oxygen Binding and Substrate Hydroxylation Step in AlkB Repair Enzymes
por: Quesne, Matthew G, et al.
Publicado: (2014)

Structural and Mutational Analysis of Escherichia coli AlkB Provides Insight into Substrate Specificity and DNA Damage Searching
por: Holland, Paul J., et al.
Publicado: (2010)

Viral AlkB proteins repair RNA damage by oxidative demethylation
por: van den Born, Erwin, et al.
Publicado: (2008)

The role of demethylase AlkB homologs in cancer
por: Li, Qiao, et al.
Publicado: (2023)

RecA stimulates AlkB-mediated direct repair of DNA adducts
por: Shivange, Gururaj, et al.
Publicado: (2016)

Sequence Dependent Repair of 1,N(6)-Ethenoadenine by DNA Repair Enzymes ALKBH2, ALKBH3, and AlkB
por: Qi, Rui, et al.
Publicado: (2021)

Bioinformatic mapping of AlkB homology domains in viruses
por: Bratlie, Marit S, et al.
Publicado: (2005)

Repair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry
por: Li, Deyu, et al.
Publicado: (2010)

Novel AlkB Dioxygenases—Alternative Models for In Silico and In Vivo Studies
por: Mielecki, Damian, et al.
Publicado: (2012)

Expression and molecular profiles of the AlkB family in ovarian serous carcinoma
por: Cai, Yuan, et al.
Publicado: (2021)

An Overview of the Electron-Transfer Proteins That Activate Alkane Monooxygenase (AlkB)
por: Williams, Shoshana C., et al.
Publicado: (2022)

The AlkB Family: Potential Prognostic Biomarkers and Therapeutic Targets in Glioblastoma
por: Feng, Songshan, et al.
Publicado: (2022)

Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis
por: Tian, Cheng, et al.
Publicado: (2022)

Kinetic studies of Escherichia coli AlkB using a new fluorescence-based assay for DNA demethylation
por: Roy, Todd W., et al.
Publicado: (2007)

Structure of AlkB–AlkG shows details of alkane terminal C–H selectivity and functionalization
Publicado: (2023)

DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro
por: Bian, Ke, et al.
Publicado: (2019)

Exocyclic Carbons Adjacent to the N(6) of Adenine are Targets for Oxidation by the Escherichia coli Adaptive Response Protein AlkB
por: Li, Deyu, et al.
Publicado: (2012)

Pseudomonas putida AlkA and AlkB Proteins Comprise Different Defense Systems for the Repair of Alkylation Damage to DNA – In Vivo, In Vitro, and In Silico Studies
por: Mielecki, Damian, et al.
Publicado: (2013)

Mechanism of Repair of Acrolein- and Malondialdehyde-Derived Exocyclic Guanine Adducts by the α-Ketoglutarate/Fe(II) Dioxygenase AlkB
por: Singh, Vipender, et al.
Publicado: (2014)

AlkB RNA demethylase homologues and N (6) ‐methyladenosine are involved in Potyvirus infection
por: Yue, Jianying, et al.
Publicado: (2022)

Divergent β-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3
por: Monsen, Vivi Talstad, et al.
Publicado: (2010)

The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases
por: Aravind, L, et al.
Publicado: (2001)

Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria
por: van den Born, Erwin, et al.
Publicado: (2009)

Alkane hydroxylase gene (alkB) phylotype composition and diversity in northern Gulf of Mexico bacterioplankton
por: Smith, Conor B., et al.
Publicado: (2013)

The Use of a Combination of alkB Primers to Better Characterize the Distribution of Alkane-Degrading Bacteria
por: Jurelevicius, Diogo, et al.
Publicado: (2013)

The bioinformatics and experimental analysis of AlkB family for prognosis and immune cell infiltration in hepatocellular carcinoma
por: Peng, Bi, et al.
Publicado: (2021)

Genome-Wide Identification and Characterization of the AlkB Gene Family in Sweet Orange (Citrus sinensis)
por: Huang, Aijun, et al.
Publicado: (2022)

Standardization of inducer-activated broad host range expression modules: debugging and refactoring an alkane-responsive AlkS/P(alkB) device
por: Arce-Rodríguez, Alejandro, et al.
Publicado: (2021)

GPo1 alkB gene expression for improvement of the degradation of diesel oil by a bacterial consortium
por: Luo, Qun, et al.
Publicado: (2015)

AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells
por: Ueda, Yuko, et al.
Publicado: (2017)

Activity of alkanmonooxygenase alkB gene in strains of hydrocarbon-oxidizing bacteria isolated from petroleum products
por: Shapiro, T.N., et al.
Publicado: (2022)

Dataset of 16S rRNA and alkB genes in hydrocarbon polluted soils of Kuwait as revealed by Pyrosequencing
por: Al-Momin, Sabah, et al.
Publicado: (2022)

Alternative Pathway for the Reaction Catalyzed by DNA Dealkylase AlkB from Ab Initio QM/MM Calculations
por: Fang, Dong, et al.
Publicado: (2014)

A Chemical Genetics Analysis of the Roles of Bypass Polymerase DinB and DNA Repair Protein AlkB in Processing N (2)-Alkylguanine Lesions In Vivo
por: Shrivastav, Nidhi, et al.
Publicado: (2014)

TP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy
por: Lee, S Y, et al.
Publicado: (2010)

A novel alkane monooxygenase (alkB) clade revealed by massive genomic survey and its dissemination association with IS elements
por: Wang, Shaojing, et al.
Publicado: (2022)

ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer
por: Tasaki, M, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_a8dgc3onilf6ns4g73i4slnfmo