G(s) protein peptidomimetics as allosteric modulators of the β(2)-adrenergic receptor

A series of G(s) protein peptidomimetics were designed and synthesised based on the published X-ray crystal structure of the active state β(2)-adrenergic receptor (β(2)AR) in complex with the G(s) protein (PDB 3SN6). We hypothesised that such peptidomimetics may function as allosteric modulators tha...

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Detalles Bibliográficos
Autores principales: Boyhus, Lotte-Emilie, Danielsen, Mia, Bengtson, Nina Smidt, Ben Achim Kunze, Micha, Kubiak, Xavier, Sminia, Tjerk J., Løper, Jacob Hartvig, Tran, Phuong Thu, Lindorff-Larsen, Kresten, Rasmussen, Søren G. F., Mathiesen, Jesper Mosolff, Pedersen, Daniel Sejer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077236/
https://www.ncbi.nlm.nih.gov/pubmed/35542596
http://dx.doi.org/10.1039/c7ra11713b

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