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Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death

Emerging clinical data show that three ceramide molecules, Cer d18:1/16:0, Cer d18:1/24:1, and Cer d18:1/24:0, are biomarkers of a fatal outcome in patients with cardiovascular disease. This finding raises basic questions about their metabolic origin, their contribution to disease pathogenesis, and...

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Detalles Bibliográficos
Autores principales:	Schmidt, Steffen, Gallego, Sandra F., Zelnik, Iris Daphne, Kovalchuk, Sergey, Albæk, Nanna, Sprenger, Richard R., Øverup, Charlotte, Pewzner-Jung, Yael, Futerman, Anthony H., Lindholm, Marie W., Jensen, Ole N., Ejsing, Christer S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077316/ https://www.ncbi.nlm.nih.gov/pubmed/34400330 http://dx.doi.org/10.1016/j.ymthe.2021.08.021

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