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Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype

Fibrillary aggregated α-synuclein (α-syn) deposition in Lewy bodies (LB) characterizes Parkinson's disease (PD) and is believed to trigger dopaminergic synaptic failure and a retrograde terminal-to-cell body neuronal degeneration. We described that the neuronal phosphoprotein synapsin III (Syn...

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Detalles Bibliográficos
Autores principales:	Faustini, Gaia, Longhena, Francesca, Masato, Anna, Bassareo, Valentina, Frau, Roberto, Klingstedt, Therése, Shirani, Hamid, Brembati, Viviana, Parrella, Edoardo, Vezzoli, Marika, Nilsson, K. Peter R., Pizzi, Marina, Spillantini, Maria Grazia, Bubacco, Luigi, Bellucci, Arianna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077321/ https://www.ncbi.nlm.nih.gov/pubmed/35038583 http://dx.doi.org/10.1016/j.ymthe.2022.01.021

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