Exploiting the tumor-suppressive activity of the androgen receptor by CDK4/6 inhibition in castration-resistant prostate cancer

The androgen receptor (AR) plays a pivotal role in driving prostate cancer (PCa) development. However, when stimulated by high levels of androgens, AR can also function as a tumor suppressor in PCa cells. While the high-dose testosterone (high-T) treatment is currently being tested in clinical trial...

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Detalles Bibliográficos
Autores principales: Han, Wanting, Liu, Mingyu, Han, Dong, Toure, Anthia A., Li, Muqing, Besschetnova, Anna, Wang, Zifeng, Patalano, Susan, Macoska, Jill A., Lam, Hung-Ming, Corey, Eva, He, Housheng Hansen, Gao, Shuai, Balk, Steven P., Cai, Changmeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077383/
https://www.ncbi.nlm.nih.gov/pubmed/35121110
http://dx.doi.org/10.1016/j.ymthe.2022.01.039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077383/
https://www.ncbi.nlm.nih.gov/pubmed/35121110
http://dx.doi.org/10.1016/j.ymthe.2022.01.039

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