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Exploiting the tumor-suppressive activity of the androgen receptor by CDK4/6 inhibition in castration-resistant prostate cancer

The androgen receptor (AR) plays a pivotal role in driving prostate cancer (PCa) development. However, when stimulated by high levels of androgens, AR can also function as a tumor suppressor in PCa cells. While the high-dose testosterone (high-T) treatment is currently being tested in clinical trial...

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Detalles Bibliográficos
Autores principales:	Han, Wanting, Liu, Mingyu, Han, Dong, Toure, Anthia A., Li, Muqing, Besschetnova, Anna, Wang, Zifeng, Patalano, Susan, Macoska, Jill A., Lam, Hung-Ming, Corey, Eva, He, Housheng Hansen, Gao, Shuai, Balk, Steven P., Cai, Changmeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077383/ https://www.ncbi.nlm.nih.gov/pubmed/35121110 http://dx.doi.org/10.1016/j.ymthe.2022.01.039

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