B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells

B-cell receptor (BCR) signaling plays a major role in the pathogenesis of B-cell malignancies and is an established target for therapy, including in chronic lymphocytic leukemia cells (CLL), the most common B-cell malignancy. We previously demonstrated that activation of BCR signaling in primary CLL...

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Detalles Bibliográficos
Autores principales: Taylor, Joe, Wilmore, Sarah, Marriot, Sophie, Rogers-Broadway, Karly-Rai, Fell, Rachel, Minton, Annabel R., Branch, Tom, Ashton-Key, Meg, Coldwell, Mark, Stevenson, Freda K., Forconi, Francesco, Steele, Andrew J., Packham, Graham, Yeomans, Alison
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077442/
https://www.ncbi.nlm.nih.gov/pubmed/35306137
http://dx.doi.org/10.1016/j.cellsig.2022.110311

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