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Stable and non-toxic ultrasmall gadolinium oxide nanoparticle colloids (coating material = polyacrylic acid) as high-performance T(1) magnetic resonance imaging contrast agents
For use as positive (T(1)) magnetic resonance imaging contrast agents (MRI-CAs), gadolinium oxide (Gd(2)O(3)) nanoparticle colloids (i.e. nanoparticles coated with hydrophilic ligands) should be stable, non-toxic, and ultrasmall in particle diameter for renal excretion. In addition, they should have...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077528/ https://www.ncbi.nlm.nih.gov/pubmed/35541201 http://dx.doi.org/10.1039/c7ra11830a |
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author | Miao, Xu Ho, Son Long Tegafaw, Tirusew Cha, Hyunsil Chang, Yongmin Oh, In Taek Yaseen, Ahmad Mohammad Marasini, Shanti Ghazanfari, Adibehalsadat Yue, Huan Chae, Kwon Seok Lee, Gang Ho |
author_facet | Miao, Xu Ho, Son Long Tegafaw, Tirusew Cha, Hyunsil Chang, Yongmin Oh, In Taek Yaseen, Ahmad Mohammad Marasini, Shanti Ghazanfari, Adibehalsadat Yue, Huan Chae, Kwon Seok Lee, Gang Ho |
author_sort | Miao, Xu |
collection | PubMed |
description | For use as positive (T(1)) magnetic resonance imaging contrast agents (MRI-CAs), gadolinium oxide (Gd(2)O(3)) nanoparticle colloids (i.e. nanoparticles coated with hydrophilic ligands) should be stable, non-toxic, and ultrasmall in particle diameter for renal excretion. In addition, they should have a high longitudinal water proton relaxivity (r(1)) and r(2)/r(1) ratio that is close to one (r(2) = transverse water proton relaxivity) for high-performance. In this study, we report ultrasmall Gd(2)O(3) nanoparticle colloids [coating material = polyacrylic acid, M(w) = ∼5100 Da] satisfying these conditions. The particle diameter was monodisperse with an average value of 2.0 ± 0.1 nm. The colloidal suspension exhibited a high r(1) value of 31.0 ± 0.1 s(−1) mM(−1) and r(2)/r(1) ratio of 1.2, where r(1) was ∼8 times higher than that of commercial Gd-chelates: the cooperative induction model was proposed to explain this. The effectiveness of the colloidal suspension as a high-performance T(1) MRI-CA was confirmed by taking in vivo T(1) MR images in a mouse after intravenous administration. Highly positive contrast enhancements were observed in various organs of the mouse such as the liver, kidneys, and bladder. The colloidal suspension was then excreted through the bladder. |
format | Online Article Text |
id | pubmed-9077528 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90775282022-05-09 Stable and non-toxic ultrasmall gadolinium oxide nanoparticle colloids (coating material = polyacrylic acid) as high-performance T(1) magnetic resonance imaging contrast agents Miao, Xu Ho, Son Long Tegafaw, Tirusew Cha, Hyunsil Chang, Yongmin Oh, In Taek Yaseen, Ahmad Mohammad Marasini, Shanti Ghazanfari, Adibehalsadat Yue, Huan Chae, Kwon Seok Lee, Gang Ho RSC Adv Chemistry For use as positive (T(1)) magnetic resonance imaging contrast agents (MRI-CAs), gadolinium oxide (Gd(2)O(3)) nanoparticle colloids (i.e. nanoparticles coated with hydrophilic ligands) should be stable, non-toxic, and ultrasmall in particle diameter for renal excretion. In addition, they should have a high longitudinal water proton relaxivity (r(1)) and r(2)/r(1) ratio that is close to one (r(2) = transverse water proton relaxivity) for high-performance. In this study, we report ultrasmall Gd(2)O(3) nanoparticle colloids [coating material = polyacrylic acid, M(w) = ∼5100 Da] satisfying these conditions. The particle diameter was monodisperse with an average value of 2.0 ± 0.1 nm. The colloidal suspension exhibited a high r(1) value of 31.0 ± 0.1 s(−1) mM(−1) and r(2)/r(1) ratio of 1.2, where r(1) was ∼8 times higher than that of commercial Gd-chelates: the cooperative induction model was proposed to explain this. The effectiveness of the colloidal suspension as a high-performance T(1) MRI-CA was confirmed by taking in vivo T(1) MR images in a mouse after intravenous administration. Highly positive contrast enhancements were observed in various organs of the mouse such as the liver, kidneys, and bladder. The colloidal suspension was then excreted through the bladder. The Royal Society of Chemistry 2018-01-16 /pmc/articles/PMC9077528/ /pubmed/35541201 http://dx.doi.org/10.1039/c7ra11830a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Miao, Xu Ho, Son Long Tegafaw, Tirusew Cha, Hyunsil Chang, Yongmin Oh, In Taek Yaseen, Ahmad Mohammad Marasini, Shanti Ghazanfari, Adibehalsadat Yue, Huan Chae, Kwon Seok Lee, Gang Ho Stable and non-toxic ultrasmall gadolinium oxide nanoparticle colloids (coating material = polyacrylic acid) as high-performance T(1) magnetic resonance imaging contrast agents |
title | Stable and non-toxic ultrasmall gadolinium oxide nanoparticle colloids (coating material = polyacrylic acid) as high-performance T(1) magnetic resonance imaging contrast agents |
title_full | Stable and non-toxic ultrasmall gadolinium oxide nanoparticle colloids (coating material = polyacrylic acid) as high-performance T(1) magnetic resonance imaging contrast agents |
title_fullStr | Stable and non-toxic ultrasmall gadolinium oxide nanoparticle colloids (coating material = polyacrylic acid) as high-performance T(1) magnetic resonance imaging contrast agents |
title_full_unstemmed | Stable and non-toxic ultrasmall gadolinium oxide nanoparticle colloids (coating material = polyacrylic acid) as high-performance T(1) magnetic resonance imaging contrast agents |
title_short | Stable and non-toxic ultrasmall gadolinium oxide nanoparticle colloids (coating material = polyacrylic acid) as high-performance T(1) magnetic resonance imaging contrast agents |
title_sort | stable and non-toxic ultrasmall gadolinium oxide nanoparticle colloids (coating material = polyacrylic acid) as high-performance t(1) magnetic resonance imaging contrast agents |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077528/ https://www.ncbi.nlm.nih.gov/pubmed/35541201 http://dx.doi.org/10.1039/c7ra11830a |
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