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A solid-phase approach for the synthesis of α-aminoboronic acid peptides
A solid-phase synthesis of α-aminoboronic acid peptides using a 1-glycerol polystyrene resin is described. Standard Fmoc solid-phase peptide chemistry is carried out to construct bortezomib and ixazomib. This approach eliminates the need for liquid–liquid extractions, silica gel column chromatograph...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077542/ https://www.ncbi.nlm.nih.gov/pubmed/35541192 http://dx.doi.org/10.1039/c7ra13479g |
| _version_ | 1784702139516321792 |
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| author | Daniels, Blake E. Stivala, Craig E. |
| author_facet | Daniels, Blake E. Stivala, Craig E. |
| author_sort | Daniels, Blake E. |
| collection | PubMed |
| description | A solid-phase synthesis of α-aminoboronic acid peptides using a 1-glycerol polystyrene resin is described. Standard Fmoc solid-phase peptide chemistry is carried out to construct bortezomib and ixazomib. This approach eliminates the need for liquid–liquid extractions, silica gel column chromatography, and HPLC purifications, as products are isolated in high purity after direct cleavage from the resin. |
| format | Online Article Text |
| id | pubmed-9077542 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | The Royal Society of Chemistry |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-90775422022-05-09 A solid-phase approach for the synthesis of α-aminoboronic acid peptides Daniels, Blake E. Stivala, Craig E. RSC Adv Chemistry A solid-phase synthesis of α-aminoboronic acid peptides using a 1-glycerol polystyrene resin is described. Standard Fmoc solid-phase peptide chemistry is carried out to construct bortezomib and ixazomib. This approach eliminates the need for liquid–liquid extractions, silica gel column chromatography, and HPLC purifications, as products are isolated in high purity after direct cleavage from the resin. The Royal Society of Chemistry 2018-01-16 /pmc/articles/PMC9077542/ /pubmed/35541192 http://dx.doi.org/10.1039/c7ra13479g Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
| spellingShingle | Chemistry Daniels, Blake E. Stivala, Craig E. A solid-phase approach for the synthesis of α-aminoboronic acid peptides |
| title | A solid-phase approach for the synthesis of α-aminoboronic acid peptides |
| title_full | A solid-phase approach for the synthesis of α-aminoboronic acid peptides |
| title_fullStr | A solid-phase approach for the synthesis of α-aminoboronic acid peptides |
| title_full_unstemmed | A solid-phase approach for the synthesis of α-aminoboronic acid peptides |
| title_short | A solid-phase approach for the synthesis of α-aminoboronic acid peptides |
| title_sort | solid-phase approach for the synthesis of α-aminoboronic acid peptides |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077542/ https://www.ncbi.nlm.nih.gov/pubmed/35541192 http://dx.doi.org/10.1039/c7ra13479g |
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