Cargando…

Cellular Therapy: The Hope for Covid-19

Coronaviruses (CoVs) are a group of very diverse viruses that cause a broad spectrum of diseases from mild to severe enteric, respiratory, systemic diseases, and common cold or pneumonia among humans and animals. This virus is associated with Middle East Respiratory Syndrome (MERS), Severe Acute Res...

Descripción completa

Detalles Bibliográficos
Autores principales: Nobari, Sima, Rezvan, Motahareh, Dashtestani, Fariba, Gangi, Mahdieh, Keshmiri Neghab, Hoda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077656/
https://www.ncbi.nlm.nih.gov/pubmed/35633981
http://dx.doi.org/10.18502/ajmb.v14i2.8883
_version_ 1784702156982452224
author Nobari, Sima
Rezvan, Motahareh
Dashtestani, Fariba
Gangi, Mahdieh
Keshmiri Neghab, Hoda
author_facet Nobari, Sima
Rezvan, Motahareh
Dashtestani, Fariba
Gangi, Mahdieh
Keshmiri Neghab, Hoda
author_sort Nobari, Sima
collection PubMed
description Coronaviruses (CoVs) are a group of very diverse viruses that cause a broad spectrum of diseases from mild to severe enteric, respiratory, systemic diseases, and common cold or pneumonia among humans and animals. This virus is associated with Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS), and lung disease that lead to Acute Respiratory Distress Syndrome (ARDS). In December 2019, researchers identified a novel coronavirus type, called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2), which was associated with symptoms of high fever, dry cough, headache, diarrhea, and reduction of White Blood Cells (WBC). Coronavirus-associated acute respiratory disease was named Coronavirus Disease 19 (COVID-19). No proven treatment has been discovered for COVID-19 so far, but researchers are trying to find the best effective way to treat this disease. Therefore, therapeutic strategies that facilitate the recovery of COVID-19 patients and reduce life-threatening complications are urgently needed now. Today, Mesenchymal Stem Cells (MSCs) and their secretion are utilized as one of the most applied tools to treat various diseases such as inflammation and cancer. MSC-derived vesicles are rich in various growth factors, cytokines, and interleukins that are produced and secreted under different physiological or pathological conditions. These vesicles were considered a suitable and effective tool in regeneration medicine because of their high power in repairing damaged tissues and modulating immune responses. Recently, evidence has shown MSC-derived vesicles through reduced expression of pro-inflammatory cytokines could improve damaged tissues in COVID-19 patients. In addition to MSCs and MSC-derived exosomes, Natural Killer (NK) cells, T cells, and platelet lysates were used against viral infection. In this review, we tried to provide an overview of MSC secretion and immune cells for COVID-19 therapy.
format Online
Article
Text
id pubmed-9077656
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Avicenna Research Institute
record_format MEDLINE/PubMed
spelling pubmed-90776562022-05-26 Cellular Therapy: The Hope for Covid-19 Nobari, Sima Rezvan, Motahareh Dashtestani, Fariba Gangi, Mahdieh Keshmiri Neghab, Hoda Avicenna J Med Biotechnol Review Article Coronaviruses (CoVs) are a group of very diverse viruses that cause a broad spectrum of diseases from mild to severe enteric, respiratory, systemic diseases, and common cold or pneumonia among humans and animals. This virus is associated with Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS), and lung disease that lead to Acute Respiratory Distress Syndrome (ARDS). In December 2019, researchers identified a novel coronavirus type, called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2), which was associated with symptoms of high fever, dry cough, headache, diarrhea, and reduction of White Blood Cells (WBC). Coronavirus-associated acute respiratory disease was named Coronavirus Disease 19 (COVID-19). No proven treatment has been discovered for COVID-19 so far, but researchers are trying to find the best effective way to treat this disease. Therefore, therapeutic strategies that facilitate the recovery of COVID-19 patients and reduce life-threatening complications are urgently needed now. Today, Mesenchymal Stem Cells (MSCs) and their secretion are utilized as one of the most applied tools to treat various diseases such as inflammation and cancer. MSC-derived vesicles are rich in various growth factors, cytokines, and interleukins that are produced and secreted under different physiological or pathological conditions. These vesicles were considered a suitable and effective tool in regeneration medicine because of their high power in repairing damaged tissues and modulating immune responses. Recently, evidence has shown MSC-derived vesicles through reduced expression of pro-inflammatory cytokines could improve damaged tissues in COVID-19 patients. In addition to MSCs and MSC-derived exosomes, Natural Killer (NK) cells, T cells, and platelet lysates were used against viral infection. In this review, we tried to provide an overview of MSC secretion and immune cells for COVID-19 therapy. Avicenna Research Institute 2022 /pmc/articles/PMC9077656/ /pubmed/35633981 http://dx.doi.org/10.18502/ajmb.v14i2.8883 Text en Copyright© 2022 Avicenna Research Institute https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Review Article
Nobari, Sima
Rezvan, Motahareh
Dashtestani, Fariba
Gangi, Mahdieh
Keshmiri Neghab, Hoda
Cellular Therapy: The Hope for Covid-19
title Cellular Therapy: The Hope for Covid-19
title_full Cellular Therapy: The Hope for Covid-19
title_fullStr Cellular Therapy: The Hope for Covid-19
title_full_unstemmed Cellular Therapy: The Hope for Covid-19
title_short Cellular Therapy: The Hope for Covid-19
title_sort cellular therapy: the hope for covid-19
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077656/
https://www.ncbi.nlm.nih.gov/pubmed/35633981
http://dx.doi.org/10.18502/ajmb.v14i2.8883
work_keys_str_mv AT nobarisima cellulartherapythehopeforcovid19
AT rezvanmotahareh cellulartherapythehopeforcovid19
AT dashtestanifariba cellulartherapythehopeforcovid19
AT gangimahdieh cellulartherapythehopeforcovid19
AT keshmirineghabhoda cellulartherapythehopeforcovid19