Eugenol triggers CD11b(+)Gr1(+) myeloid-derived suppressor cell apoptosis via endogenous apoptosis pathway

To study the effect and underlying molecular mechanism of eugenol on CD11b(+)Gr1(+) myeloid-derived suppressor cells (MDSCs). The effect of eugenol on the inhibition of immortalized MDSC cell line MSC-2 and murine peritoneal macrophages was detected by MTT. Flow cytometry was used to detect the pro-...

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Detalles Bibliográficos
Autores principales: Ding, Ying, Yang, Zecheng, Zhang, Wensheng, Xu, Yuwei, Wang, Yuanyuan, Hu, Minghua, Ma, Fangli, Long, Hanan, Tao, Ning, Qin, Zhihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077712/
https://www.ncbi.nlm.nih.gov/pubmed/35542913
http://dx.doi.org/10.1039/c7ra13499a
Descripción
Sumario:To study the effect and underlying molecular mechanism of eugenol on CD11b(+)Gr1(+) myeloid-derived suppressor cells (MDSCs). The effect of eugenol on the inhibition of immortalized MDSC cell line MSC-2 and murine peritoneal macrophages was detected by MTT. Flow cytometry was used to detect the pro-apoptosis effect of eugenol on MDSCs. The expression levels of apoptosis-related proteins were detected by western blot. Eugenol has a selective inhibitory effect on MDSCs in a dose-dependent manner, which activates an endogenous apoptosis pathway, leading to apoptosis. Eugenol promotes the apoptosis of MDSCs via the intrinsic pathway.

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