Eugenol triggers CD11b(+)Gr1(+) myeloid-derived suppressor cell apoptosis via endogenous apoptosis pathway

To study the effect and underlying molecular mechanism of eugenol on CD11b(+)Gr1(+) myeloid-derived suppressor cells (MDSCs). The effect of eugenol on the inhibition of immortalized MDSC cell line MSC-2 and murine peritoneal macrophages was detected by MTT. Flow cytometry was used to detect the pro-...

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Autores principales: Ding, Ying, Yang, Zecheng, Zhang, Wensheng, Xu, Yuwei, Wang, Yuanyuan, Hu, Minghua, Ma, Fangli, Long, Hanan, Tao, Ning, Qin, Zhihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077712/
https://www.ncbi.nlm.nih.gov/pubmed/35542913
http://dx.doi.org/10.1039/c7ra13499a
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author Ding, Ying
Yang, Zecheng
Zhang, Wensheng
Xu, Yuwei
Wang, Yuanyuan
Hu, Minghua
Ma, Fangli
Long, Hanan
Tao, Ning
Qin, Zhihai
author_facet Ding, Ying
Yang, Zecheng
Zhang, Wensheng
Xu, Yuwei
Wang, Yuanyuan
Hu, Minghua
Ma, Fangli
Long, Hanan
Tao, Ning
Qin, Zhihai
author_sort Ding, Ying
collection PubMed
description To study the effect and underlying molecular mechanism of eugenol on CD11b(+)Gr1(+) myeloid-derived suppressor cells (MDSCs). The effect of eugenol on the inhibition of immortalized MDSC cell line MSC-2 and murine peritoneal macrophages was detected by MTT. Flow cytometry was used to detect the pro-apoptosis effect of eugenol on MDSCs. The expression levels of apoptosis-related proteins were detected by western blot. Eugenol has a selective inhibitory effect on MDSCs in a dose-dependent manner, which activates an endogenous apoptosis pathway, leading to apoptosis. Eugenol promotes the apoptosis of MDSCs via the intrinsic pathway.
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spelling pubmed-90777122022-05-09 Eugenol triggers CD11b(+)Gr1(+) myeloid-derived suppressor cell apoptosis via endogenous apoptosis pathway Ding, Ying Yang, Zecheng Zhang, Wensheng Xu, Yuwei Wang, Yuanyuan Hu, Minghua Ma, Fangli Long, Hanan Tao, Ning Qin, Zhihai RSC Adv Chemistry To study the effect and underlying molecular mechanism of eugenol on CD11b(+)Gr1(+) myeloid-derived suppressor cells (MDSCs). The effect of eugenol on the inhibition of immortalized MDSC cell line MSC-2 and murine peritoneal macrophages was detected by MTT. Flow cytometry was used to detect the pro-apoptosis effect of eugenol on MDSCs. The expression levels of apoptosis-related proteins were detected by western blot. Eugenol has a selective inhibitory effect on MDSCs in a dose-dependent manner, which activates an endogenous apoptosis pathway, leading to apoptosis. Eugenol promotes the apoptosis of MDSCs via the intrinsic pathway. The Royal Society of Chemistry 2018-01-19 /pmc/articles/PMC9077712/ /pubmed/35542913 http://dx.doi.org/10.1039/c7ra13499a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Ding, Ying
Yang, Zecheng
Zhang, Wensheng
Xu, Yuwei
Wang, Yuanyuan
Hu, Minghua
Ma, Fangli
Long, Hanan
Tao, Ning
Qin, Zhihai
Eugenol triggers CD11b(+)Gr1(+) myeloid-derived suppressor cell apoptosis via endogenous apoptosis pathway
title Eugenol triggers CD11b(+)Gr1(+) myeloid-derived suppressor cell apoptosis via endogenous apoptosis pathway
title_full Eugenol triggers CD11b(+)Gr1(+) myeloid-derived suppressor cell apoptosis via endogenous apoptosis pathway
title_fullStr Eugenol triggers CD11b(+)Gr1(+) myeloid-derived suppressor cell apoptosis via endogenous apoptosis pathway
title_full_unstemmed Eugenol triggers CD11b(+)Gr1(+) myeloid-derived suppressor cell apoptosis via endogenous apoptosis pathway
title_short Eugenol triggers CD11b(+)Gr1(+) myeloid-derived suppressor cell apoptosis via endogenous apoptosis pathway
title_sort eugenol triggers cd11b(+)gr1(+) myeloid-derived suppressor cell apoptosis via endogenous apoptosis pathway
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077712/
https://www.ncbi.nlm.nih.gov/pubmed/35542913
http://dx.doi.org/10.1039/c7ra13499a
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