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Young‐onset diabetes patients in Thailand: Data from Thai Type 1 Diabetes and Diabetes diagnosed Age before 30 years Registry, Care and Network (T1DDAR CN)
AIMS/INTRODUCTION: There is a lack of current information regarding young‐onset diabetes in Thailand. Thus, the objectives of this study were to describe the types of diabetes, the clinical characteristics, the treatment regimens and achievement of glycemic control in Thai patients with young‐onset...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077742/ https://www.ncbi.nlm.nih.gov/pubmed/34890117 http://dx.doi.org/10.1111/jdi.13732 |
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author | Dejkhamron, Prapai Santiprabhob, Jeerunda Likitmaskul, Supawadee Deerochanawong, Chaicharn Rawdaree, Petch Tharavanij, Thipaporn Reutrakul, Sirimon Kongkanka, Chawkaew Suprasongsin, Chittiwat Numbenjapon, Nawaporn Sahakitrungruang, Taninee Lertwattanarak, Raweewan Engkakul, Pontipa Sriwijitkamol, Apiradee Korwutthikulrangsri, Manassawee Leelawattana, Rattana Phimphilai, Mattabhorn Potisat, Somkiat Khananuraksa, Panthep Kunsuikmengrai, Kemarasami Nitiyanant, Wannee |
author_facet | Dejkhamron, Prapai Santiprabhob, Jeerunda Likitmaskul, Supawadee Deerochanawong, Chaicharn Rawdaree, Petch Tharavanij, Thipaporn Reutrakul, Sirimon Kongkanka, Chawkaew Suprasongsin, Chittiwat Numbenjapon, Nawaporn Sahakitrungruang, Taninee Lertwattanarak, Raweewan Engkakul, Pontipa Sriwijitkamol, Apiradee Korwutthikulrangsri, Manassawee Leelawattana, Rattana Phimphilai, Mattabhorn Potisat, Somkiat Khananuraksa, Panthep Kunsuikmengrai, Kemarasami Nitiyanant, Wannee |
author_sort | Dejkhamron, Prapai |
collection | PubMed |
description | AIMS/INTRODUCTION: There is a lack of current information regarding young‐onset diabetes in Thailand. Thus, the objectives of this study were to describe the types of diabetes, the clinical characteristics, the treatment regimens and achievement of glycemic control in Thai patients with young‐onset diabetes. MATERIALS AND METHODS: Data of 2,844 patients with diabetes onset before 30 years‐of‐age were retrospectively reviewed from a diabetes registry comprising 31 hospitals in Thailand. Gestational diabetes was excluded. RESULTS: Based on clinical criteria, type 1 diabetes was identified in 62.6% of patients, type 2 diabetes in 30.7%, neonatal diabetes in 0.8%, other monogenic diabetes in 1.7%, secondary diabetes in 3.0%, genetic syndromes associated with diabetes in 0.9% and other types of diabetes in 0.4%. Type 1 diabetes accounted for 72.3% of patients with age of onset <20 years. The proportion of type 2 diabetes was 61.0% of patients with age of onset from 20 to <30 years. Intensive insulin treatment was prescribed to 55.2% of type 1 diabetes patients. Oral antidiabetic agent alone was used in 50.8% of type 2 diabetes patients, whereas 44.1% received insulin treatment. Most monogenic diabetes, secondary diabetes and genetic syndromes associated with diabetes required insulin treatment. Achievement of glycemic control was identified in 12.4% of type 1 diabetes patients, 30% of type 2 diabetes patients, 36.4% of neonatal diabetes patients, 28.3% of other monogenic diabetes patients, 45.6% of secondary diabetes patients and 28% of genetic syndromes associated with diabetes patients. CONCLUSION: In this registry, type 1 diabetes remains the most common type and the prevalence of type 2 diabetes increases with age. The majority of patients did not achieve the glycemic target, especially type 1 diabetes patients. |
format | Online Article Text |
id | pubmed-9077742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90777422022-05-13 Young‐onset diabetes patients in Thailand: Data from Thai Type 1 Diabetes and Diabetes diagnosed Age before 30 years Registry, Care and Network (T1DDAR CN) Dejkhamron, Prapai Santiprabhob, Jeerunda Likitmaskul, Supawadee Deerochanawong, Chaicharn Rawdaree, Petch Tharavanij, Thipaporn Reutrakul, Sirimon Kongkanka, Chawkaew Suprasongsin, Chittiwat Numbenjapon, Nawaporn Sahakitrungruang, Taninee Lertwattanarak, Raweewan Engkakul, Pontipa Sriwijitkamol, Apiradee Korwutthikulrangsri, Manassawee Leelawattana, Rattana Phimphilai, Mattabhorn Potisat, Somkiat Khananuraksa, Panthep Kunsuikmengrai, Kemarasami Nitiyanant, Wannee J Diabetes Investig Original Articles AIMS/INTRODUCTION: There is a lack of current information regarding young‐onset diabetes in Thailand. Thus, the objectives of this study were to describe the types of diabetes, the clinical characteristics, the treatment regimens and achievement of glycemic control in Thai patients with young‐onset diabetes. MATERIALS AND METHODS: Data of 2,844 patients with diabetes onset before 30 years‐of‐age were retrospectively reviewed from a diabetes registry comprising 31 hospitals in Thailand. Gestational diabetes was excluded. RESULTS: Based on clinical criteria, type 1 diabetes was identified in 62.6% of patients, type 2 diabetes in 30.7%, neonatal diabetes in 0.8%, other monogenic diabetes in 1.7%, secondary diabetes in 3.0%, genetic syndromes associated with diabetes in 0.9% and other types of diabetes in 0.4%. Type 1 diabetes accounted for 72.3% of patients with age of onset <20 years. The proportion of type 2 diabetes was 61.0% of patients with age of onset from 20 to <30 years. Intensive insulin treatment was prescribed to 55.2% of type 1 diabetes patients. Oral antidiabetic agent alone was used in 50.8% of type 2 diabetes patients, whereas 44.1% received insulin treatment. Most monogenic diabetes, secondary diabetes and genetic syndromes associated with diabetes required insulin treatment. Achievement of glycemic control was identified in 12.4% of type 1 diabetes patients, 30% of type 2 diabetes patients, 36.4% of neonatal diabetes patients, 28.3% of other monogenic diabetes patients, 45.6% of secondary diabetes patients and 28% of genetic syndromes associated with diabetes patients. CONCLUSION: In this registry, type 1 diabetes remains the most common type and the prevalence of type 2 diabetes increases with age. The majority of patients did not achieve the glycemic target, especially type 1 diabetes patients. John Wiley and Sons Inc. 2022-01-06 2022-05 /pmc/articles/PMC9077742/ /pubmed/34890117 http://dx.doi.org/10.1111/jdi.13732 Text en © 2021 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Dejkhamron, Prapai Santiprabhob, Jeerunda Likitmaskul, Supawadee Deerochanawong, Chaicharn Rawdaree, Petch Tharavanij, Thipaporn Reutrakul, Sirimon Kongkanka, Chawkaew Suprasongsin, Chittiwat Numbenjapon, Nawaporn Sahakitrungruang, Taninee Lertwattanarak, Raweewan Engkakul, Pontipa Sriwijitkamol, Apiradee Korwutthikulrangsri, Manassawee Leelawattana, Rattana Phimphilai, Mattabhorn Potisat, Somkiat Khananuraksa, Panthep Kunsuikmengrai, Kemarasami Nitiyanant, Wannee Young‐onset diabetes patients in Thailand: Data from Thai Type 1 Diabetes and Diabetes diagnosed Age before 30 years Registry, Care and Network (T1DDAR CN) |
title | Young‐onset diabetes patients in Thailand: Data from Thai Type 1 Diabetes and Diabetes diagnosed Age before 30 years Registry, Care and Network (T1DDAR CN) |
title_full | Young‐onset diabetes patients in Thailand: Data from Thai Type 1 Diabetes and Diabetes diagnosed Age before 30 years Registry, Care and Network (T1DDAR CN) |
title_fullStr | Young‐onset diabetes patients in Thailand: Data from Thai Type 1 Diabetes and Diabetes diagnosed Age before 30 years Registry, Care and Network (T1DDAR CN) |
title_full_unstemmed | Young‐onset diabetes patients in Thailand: Data from Thai Type 1 Diabetes and Diabetes diagnosed Age before 30 years Registry, Care and Network (T1DDAR CN) |
title_short | Young‐onset diabetes patients in Thailand: Data from Thai Type 1 Diabetes and Diabetes diagnosed Age before 30 years Registry, Care and Network (T1DDAR CN) |
title_sort | young‐onset diabetes patients in thailand: data from thai type 1 diabetes and diabetes diagnosed age before 30 years registry, care and network (t1ddar cn) |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077742/ https://www.ncbi.nlm.nih.gov/pubmed/34890117 http://dx.doi.org/10.1111/jdi.13732 |
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