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Combined spectroscopy methods and molecular simulations for the binding properties of trametinib to human serum albumin

Trametinib is a novel anticancer drug for treating metastatic cutaneous melanoma. The present study probed into the binding of trametinib to human serum albumin (HSA) through spectroscopy methods and molecular simulations. Trametinib could quench the fluorescence of HSA through static quenching whic...

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Detalles Bibliográficos
Autores principales:	Suo, Zili, Sun, Qiaomei, Yang, Hongqin, Tang, Peixiao, Gan, Ruixue, Xiong, Xinnuo, Li, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077761/ https://www.ncbi.nlm.nih.gov/pubmed/35539509 http://dx.doi.org/10.1039/c7ra12890h

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