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Efficient empirical likelihood inference for recovery rate of COVID19 under double-censoring

Doubly censored data are very common in epidemiology studies. Ignoring censorship in the analysis may lead to biased parameter estimation. In this paper, we highlight that the publicly available COVID19 data may involve high percentage of double-censoring and point out the importance of dealing with...

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Autores principales: Hu, Jie, Liang, Wei, Dai, Hongsheng, Bao, Yanchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077865/
https://www.ncbi.nlm.nih.gov/pubmed/35573146
http://dx.doi.org/10.1016/j.jspi.2022.04.005
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author Hu, Jie
Liang, Wei
Dai, Hongsheng
Bao, Yanchun
author_facet Hu, Jie
Liang, Wei
Dai, Hongsheng
Bao, Yanchun
author_sort Hu, Jie
collection PubMed
description Doubly censored data are very common in epidemiology studies. Ignoring censorship in the analysis may lead to biased parameter estimation. In this paper, we highlight that the publicly available COVID19 data may involve high percentage of double-censoring and point out the importance of dealing with such missing information in order to achieve better forecasting results. Existing statistical methods for doubly censored data may suffer from the convergence problems of the EM algorithms or may not be good enough for small sample sizes. This paper develops a new empirical likelihood method to analyze the recovery rate of COVID19 based on a doubly censored dataset. The efficient influence function of the parameter of interest is used to define the empirical likelihood (EL) ratio. We prove that [Formula: see text] (EL-ratio) asymptotically follows a standard [Formula: see text] distribution. This new method does not require any scale parameter adjustment for the log-likelihood ratio and thus does not suffer from the convergence problems involved in traditional EM-type algorithms. Finite sample simulation results show that this method provides much less biased estimate than existing methods, when censoring percentage is large. The application to COVID19 data will help researchers in other field to achieve better estimates and forecasting results.
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spelling pubmed-90778652022-05-09 Efficient empirical likelihood inference for recovery rate of COVID19 under double-censoring Hu, Jie Liang, Wei Dai, Hongsheng Bao, Yanchun J Stat Plan Inference Article Doubly censored data are very common in epidemiology studies. Ignoring censorship in the analysis may lead to biased parameter estimation. In this paper, we highlight that the publicly available COVID19 data may involve high percentage of double-censoring and point out the importance of dealing with such missing information in order to achieve better forecasting results. Existing statistical methods for doubly censored data may suffer from the convergence problems of the EM algorithms or may not be good enough for small sample sizes. This paper develops a new empirical likelihood method to analyze the recovery rate of COVID19 based on a doubly censored dataset. The efficient influence function of the parameter of interest is used to define the empirical likelihood (EL) ratio. We prove that [Formula: see text] (EL-ratio) asymptotically follows a standard [Formula: see text] distribution. This new method does not require any scale parameter adjustment for the log-likelihood ratio and thus does not suffer from the convergence problems involved in traditional EM-type algorithms. Finite sample simulation results show that this method provides much less biased estimate than existing methods, when censoring percentage is large. The application to COVID19 data will help researchers in other field to achieve better estimates and forecasting results. Elsevier B.V. 2022-12 2022-05-07 /pmc/articles/PMC9077865/ /pubmed/35573146 http://dx.doi.org/10.1016/j.jspi.2022.04.005 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Hu, Jie
Liang, Wei
Dai, Hongsheng
Bao, Yanchun
Efficient empirical likelihood inference for recovery rate of COVID19 under double-censoring
title Efficient empirical likelihood inference for recovery rate of COVID19 under double-censoring
title_full Efficient empirical likelihood inference for recovery rate of COVID19 under double-censoring
title_fullStr Efficient empirical likelihood inference for recovery rate of COVID19 under double-censoring
title_full_unstemmed Efficient empirical likelihood inference for recovery rate of COVID19 under double-censoring
title_short Efficient empirical likelihood inference for recovery rate of COVID19 under double-censoring
title_sort efficient empirical likelihood inference for recovery rate of covid19 under double-censoring
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077865/
https://www.ncbi.nlm.nih.gov/pubmed/35573146
http://dx.doi.org/10.1016/j.jspi.2022.04.005
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