BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia

BACKGROUND: The BIN1 locus contains the second-most significant genetic risk factor for late-onset Alzheimer’s disease. BIN1 undergoes alternate splicing to generate tissue- and cell-type-specific BIN1 isoforms, which regulate membrane dynamics in a range of crucial cellular processes. Whilst the ex...

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Detalles Bibliográficos
Autores principales: Sudwarts, Ari, Ramesha, Supriya, Gao, Tianwen, Ponnusamy, Moorthi, Wang, Shuai, Hansen, Mitchell, Kozlova, Alena, Bitarafan, Sara, Kumar, Prateek, Beaulieu-Abdelahad, David, Zhang, Xiaolin, Collier, Lisa, Szekeres, Charles, Wood, Levi B., Duan, Jubao, Thinakaran, Gopal, Rangaraju, Srikant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077874/
https://www.ncbi.nlm.nih.gov/pubmed/35526014
http://dx.doi.org/10.1186/s13024-022-00535-x

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