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Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome

BACKGROUND: Interleukin-2 (IL-2) and the high-affinity IL-2 receptor (IL-2R) are essential for the survival of regulatory T cells (Tregs) which are the main players in immune tolerance and prevention of autoimmune diseases. Sjögren’s syndrome (SS) is a chronic autoimmune disease predominantly affect...

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Detalles Bibliográficos
Autores principales:	Keindl, Magdalena, Davies, Richard, Bergum, Brith, Brun, Johan G., Hammenfors, Daniel, Jonsson, Roland, Lyssenko, Valeriya, Appel, Silke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077945/ https://www.ncbi.nlm.nih.gov/pubmed/35526080 http://dx.doi.org/10.1186/s13075-022-02769-y

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