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Pharmacological agents for the prevention of colistin-induced nephrotoxicity
BACKGROUND: Colistin is a polymyxin antibiotic which has been used for treatment of Gram-negative infections, but it was withdrawn due to its nephrotoxicity. However, colistin has gained its popularity in recent years due to the reemergence of multidrug resistant Gram-negative infections and drug-in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077985/ https://www.ncbi.nlm.nih.gov/pubmed/35525994 http://dx.doi.org/10.1186/s40001-022-00689-w |
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author | Mirjalili, Mahtabalsadat Mirzaei, Ehsan Vazin, Afsaneh |
author_facet | Mirjalili, Mahtabalsadat Mirzaei, Ehsan Vazin, Afsaneh |
author_sort | Mirjalili, Mahtabalsadat |
collection | PubMed |
description | BACKGROUND: Colistin is a polymyxin antibiotic which has been used for treatment of Gram-negative infections, but it was withdrawn due to its nephrotoxicity. However, colistin has gained its popularity in recent years due to the reemergence of multidrug resistant Gram-negative infections and drug-induced toxicity is considered as the main obstacle for using this valuable antibiotic. RESULTS: In total, 30 articles, including 29 animal studies and one clinical trial were included in this study. These compounds, including aged black garlic extract, albumin fragments, alpha lipoic acid, astaxanthin, baicalein, chrysin, cilastatin, colchicine, curcumin, cytochrome c, dexmedetomidine, gelofusine, grape seed proanthocyanidin extract, hesperidin, luteolin, lycopene, melatonin, methionine, N-acetylcysteine, silymarin, taurine, vitamin C, and vitamin E exhibited beneficial effects in most of the published works. CONCLUSIONS: In this review, the authors have attempted to review the available literature on the use of several compounds for prevention or attenuation of colistin-induced nephrotoxicity. Most of the studied compounds were potent antioxidants, and it seems that using antioxidants concomitantly can have a protective effect during the colistin exposure. |
format | Online Article Text |
id | pubmed-9077985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-90779852022-05-09 Pharmacological agents for the prevention of colistin-induced nephrotoxicity Mirjalili, Mahtabalsadat Mirzaei, Ehsan Vazin, Afsaneh Eur J Med Res Research BACKGROUND: Colistin is a polymyxin antibiotic which has been used for treatment of Gram-negative infections, but it was withdrawn due to its nephrotoxicity. However, colistin has gained its popularity in recent years due to the reemergence of multidrug resistant Gram-negative infections and drug-induced toxicity is considered as the main obstacle for using this valuable antibiotic. RESULTS: In total, 30 articles, including 29 animal studies and one clinical trial were included in this study. These compounds, including aged black garlic extract, albumin fragments, alpha lipoic acid, astaxanthin, baicalein, chrysin, cilastatin, colchicine, curcumin, cytochrome c, dexmedetomidine, gelofusine, grape seed proanthocyanidin extract, hesperidin, luteolin, lycopene, melatonin, methionine, N-acetylcysteine, silymarin, taurine, vitamin C, and vitamin E exhibited beneficial effects in most of the published works. CONCLUSIONS: In this review, the authors have attempted to review the available literature on the use of several compounds for prevention or attenuation of colistin-induced nephrotoxicity. Most of the studied compounds were potent antioxidants, and it seems that using antioxidants concomitantly can have a protective effect during the colistin exposure. BioMed Central 2022-05-07 /pmc/articles/PMC9077985/ /pubmed/35525994 http://dx.doi.org/10.1186/s40001-022-00689-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Mirjalili, Mahtabalsadat Mirzaei, Ehsan Vazin, Afsaneh Pharmacological agents for the prevention of colistin-induced nephrotoxicity |
title | Pharmacological agents for the prevention of colistin-induced nephrotoxicity |
title_full | Pharmacological agents for the prevention of colistin-induced nephrotoxicity |
title_fullStr | Pharmacological agents for the prevention of colistin-induced nephrotoxicity |
title_full_unstemmed | Pharmacological agents for the prevention of colistin-induced nephrotoxicity |
title_short | Pharmacological agents for the prevention of colistin-induced nephrotoxicity |
title_sort | pharmacological agents for the prevention of colistin-induced nephrotoxicity |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077985/ https://www.ncbi.nlm.nih.gov/pubmed/35525994 http://dx.doi.org/10.1186/s40001-022-00689-w |
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