Optimized Cas9:sgRNA delivery efficiently generates biallelic MSTN knockout sheep without affecting meat quality

BACKGROUND: CRISPR/Cas9-based genome-editing systems have been used to efficiently engineer livestock species with precise genetic alterations intended for biomedical and agricultural applications. Previously, we have successfully generated gene-edited sheep and goats via one-cell-stage embryonic mi...

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Detalles Bibliográficos
Autores principales: Zhou, Shiwei, Kalds, Peter, Luo, Qi, Sun, Kexin, Zhao, Xiaoe, Gao, Yawei, Cai, Bei, Huang, Shuhong, Kou, Qifang, Petersen, Bjoern, Chen, Yulin, Ma, Baohua, Wang, Xiaolong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078021/
https://www.ncbi.nlm.nih.gov/pubmed/35524183
http://dx.doi.org/10.1186/s12864-022-08594-6

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