Transition-metal-free regioselective C–H halogenation of imidazo[1,2-a]pyridines: sodium chlorite/bromite as the halogen source

A facile transition-metal-free regioselective halogenation of imidazo[1,2-a]pyridines using sodium chlorite/bromite as the halogen source is presented. The reaction has provided an efficient method for the formation of C–Cl or C–Br bonds to synthesize 3-chloro or 3-bromo-imidazo[1,2-a]pyridines whic...

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Autores principales: Li, Junxuan, Tang, Jiayi, Wu, Yuanheng, He, Qiuxing, Yu, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078039/
https://www.ncbi.nlm.nih.gov/pubmed/35539548
http://dx.doi.org/10.1039/c7ra12100h
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author Li, Junxuan
Tang, Jiayi
Wu, Yuanheng
He, Qiuxing
Yu, Yue
author_facet Li, Junxuan
Tang, Jiayi
Wu, Yuanheng
He, Qiuxing
Yu, Yue
author_sort Li, Junxuan
collection PubMed
description A facile transition-metal-free regioselective halogenation of imidazo[1,2-a]pyridines using sodium chlorite/bromite as the halogen source is presented. The reaction has provided an efficient method for the formation of C–Cl or C–Br bonds to synthesize 3-chloro or 3-bromo-imidazo[1,2-a]pyridines which were then efficiently transformed into imidazo[1,2-a]pyridine core π-systems by Suzuki–Miyaura reactions.
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spelling pubmed-90780392022-05-09 Transition-metal-free regioselective C–H halogenation of imidazo[1,2-a]pyridines: sodium chlorite/bromite as the halogen source Li, Junxuan Tang, Jiayi Wu, Yuanheng He, Qiuxing Yu, Yue RSC Adv Chemistry A facile transition-metal-free regioselective halogenation of imidazo[1,2-a]pyridines using sodium chlorite/bromite as the halogen source is presented. The reaction has provided an efficient method for the formation of C–Cl or C–Br bonds to synthesize 3-chloro or 3-bromo-imidazo[1,2-a]pyridines which were then efficiently transformed into imidazo[1,2-a]pyridine core π-systems by Suzuki–Miyaura reactions. The Royal Society of Chemistry 2018-02-01 /pmc/articles/PMC9078039/ /pubmed/35539548 http://dx.doi.org/10.1039/c7ra12100h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Li, Junxuan
Tang, Jiayi
Wu, Yuanheng
He, Qiuxing
Yu, Yue
Transition-metal-free regioselective C–H halogenation of imidazo[1,2-a]pyridines: sodium chlorite/bromite as the halogen source
title Transition-metal-free regioselective C–H halogenation of imidazo[1,2-a]pyridines: sodium chlorite/bromite as the halogen source
title_full Transition-metal-free regioselective C–H halogenation of imidazo[1,2-a]pyridines: sodium chlorite/bromite as the halogen source
title_fullStr Transition-metal-free regioselective C–H halogenation of imidazo[1,2-a]pyridines: sodium chlorite/bromite as the halogen source
title_full_unstemmed Transition-metal-free regioselective C–H halogenation of imidazo[1,2-a]pyridines: sodium chlorite/bromite as the halogen source
title_short Transition-metal-free regioselective C–H halogenation of imidazo[1,2-a]pyridines: sodium chlorite/bromite as the halogen source
title_sort transition-metal-free regioselective c–h halogenation of imidazo[1,2-a]pyridines: sodium chlorite/bromite as the halogen source
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078039/
https://www.ncbi.nlm.nih.gov/pubmed/35539548
http://dx.doi.org/10.1039/c7ra12100h
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