Cargando…

Discovery of VEGFR2 inhibitors by integrating naïve Bayesian classification, molecular docking and drug screening approaches

The high morbidity and mortality of cancer make it one of the leading causes of global death, thus it is an urgent need to develop effective drugs for cancer therapy. Vascular endothelial growth factor receptor-2 (VEGFR2) acts as a central modulator of angiogenesis, and is therefore an important pha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kang, De, Pang, Xiaocong, Lian, Wenwen, Xu, Lvjie, Wang, Jinhua, Jia, Hao, Zhang, Baoyue, Liu, Ai-Lin, Du, Guan-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078101/ https://www.ncbi.nlm.nih.gov/pubmed/35542432 http://dx.doi.org/10.1039/c7ra12259d

Ejemplares similares

The Bioinformatic Analysis of the Dysregulated Genes and MicroRNAs in Entorhinal Cortex, Hippocampus, and Blood for Alzheimer's Disease
por: Pang, Xiaocong, et al.
Publicado: (2017)

Identification of Estrogen Receptor α Antagonists from Natural Products via In Vitro and In Silico Approaches
por: Pang, Xiaocong, et al.
Publicado: (2018)

Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies
por: Elkaeed, Eslam B., et al.
Publicado: (2022)

Screening of cytochrome P450 3A4 inhibitors via in silico and in vitro approaches
por: Pang, Xiaocong, et al.
Publicado: (2018)

Building an Ensemble of Fine-Tuned Naive Bayesian Classifiers for Text Classification
por: El Hindi, Khalil, et al.
Publicado: (2018)

Molecular docking analysis of C-phycocyanin with VEGFR2
por: Bannu, Saira M, et al.
Publicado: (2020)

DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice
por: Lian, Wenwen, et al.
Publicado: (2017)

Evaluation of Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors as Potential Anti-Alzheimer’s Disease Agents Using Pharmacophore, 3D-QSAR and Molecular Docking Approaches
por: Pang, Xiaocong, et al.
Publicado: (2017)

A Bayesian latent class extension of naive Bayesian classifier and its application to the classification of gastric cancer patients
por: Gohari, Kimiya, et al.
Publicado: (2023)

Discovery of YopE Inhibitors by Pharmacophore-Based Virtual Screening and Docking
por: Ozbuyukkaya, Gizem, et al.
Publicado: (2013)

The Discovery of Aurora Kinase Inhibitor by Multi-Docking-Based Virtual Screening
por: Kim, Jun-Tae, et al.
Publicado: (2014)

Multi-Protection of DL0410 in Ameliorating Cognitive Defects in D-Galactose Induced Aging Mice
por: Lian, Wenwen, et al.
Publicado: (2017)

Synthesis, Anticancer Screening of Some Novel Trimethoxy Quinazolines and VEGFR2, EGFR Tyrosine Kinase Inhibitors Assay; Molecular Docking Studies
por: Altamimi, Abdulmalik S., et al.
Publicado: (2021)

The use of machine learning modeling, virtual screening, molecular docking, and molecular dynamics simulations to identify potential VEGFR2 kinase inhibitors
por: Salimi, Abbas, et al.
Publicado: (2022)

The effect of training set on the classification of honey bee gut microbiota using the Naïve Bayesian Classifier
por: Newton, Irene LG, et al.
Publicado: (2012)

Synthesis and Molecular Docking of Some Novel 3-Thiazolyl-Coumarins as Inhibitors of VEGFR-2 Kinase
por: Abolibda, Tariq Z., et al.
Publicado: (2023)

Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent
por: Jiang, Zongru, et al.
Publicado: (2020)

A Framework for Instantaneous Driver Drowsiness Detection Based on Improved HOG Features and Naïve Bayesian Classification
por: Bakheet, Samy, et al.
Publicado: (2021)

Adaptive Naive Bayesian Anti-Spam Engine
por: Gajewski, W P
Publicado: (2006)

Full “Laplacianised” posterior naive Bayesian algorithm
por: Mussa, Hamse Y, et al.
Publicado: (2013)

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
por: Shaldam, Moataz A., et al.
Publicado: (2023)

Bayesian approach to discovery
por: Berger, James
Publicado: (2011)

The Bayesian Approach to Discovery
por: Berger, James
Publicado: (2011)

Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics
por: Mamer, Spencer B., et al.
Publicado: (2017)

Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors
por: Abdallah, Abdallah E., et al.
Publicado: (2022)

AlzhCPI: A knowledge base for predicting chemical-protein interactions towards Alzheimer’s disease
por: Fang, Jiansong, et al.
Publicado: (2017)

Combined Naïve Bayesian, Chemical Fingerprints and Molecular Docking Classifiers to Model and Predict Androgen Receptor Binding Data for Environmentally- and Health-Sensitive Substances
por: García-Sosa, Alfonso T., et al.
Publicado: (2021)

Pharmacophore Modeling, Virtual Screening, and Molecular Docking Studies for Discovery of Novel Akt2 Inhibitors
por: Fei, Jia, et al.
Publicado: (2013)

Discovery of Oxime Ethers as Hepatitis B Virus (HBV) Inhibitors by Docking, Screening and In Vitro Investigation
por: Tan, Jie, et al.
Publicado: (2018)

Elucidating Antiangiogenic Potential of Rauwolfia serpentina: VEGFR-2 Targeting-Based Molecular Docking Study
por: Abuzenadah, Adel M., et al.
Publicado: (2022)

In Silico Discovery of Potential VEGFR-2 Inhibitors from Natural Derivatives for Anti-Angiogenesis Therapy
por: Li, Jing, et al.
Publicado: (2014)

Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents
por: Aziz, Marwa A., et al.
Publicado: (2016)

DL0410 Alleviates Memory Impairment in D-Galactose-Induced Aging Rats by Suppressing Neuroinflammation via the TLR4/MyD88/NF-κB Pathway
por: Zhang, Baoyue, et al.
Publicado: (2021)

Discovery of Multitarget-Directed Ligands Against Influenza A Virus From Compound Yizhihao Through a Predictive System for Compound-Protein Interactions
por: Xu, Lvjie, et al.
Publicado: (2020)

Class imbalance learning with Bayesian optimization applied in drug discovery
por: Guan, Shenmin, et al.
Publicado: (2022)

Synthesis of Novel Phthalazinedione-Based Derivatives with Promising Cytotoxic, Anti-bacterial, and Molecular Docking Studies as VEGFR2 Inhibitors
por: El Rayes, Samir M., et al.
Publicado: (2022)

Design, synthesis, and docking studies of novel pyrazole-based scaffolds and their evaluation as VEGFR2 inhibitors in the treatment of prostate cancer
por: Soliman, Dalia H., et al.
Publicado: (2023)

Lovastatin Inhibits VEGFR and AKT Activation: Synergistic Cytotoxicity in Combination with VEGFR Inhibitors
por: Zhao, Tong T., et al.
Publicado: (2010)

The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies
por: Lu, Shin-Hua, et al.
Publicado: (2011)

3D Pharmacophore-Based Virtual Screening and Docking Approaches toward the Discovery of Novel HPPD Inhibitors
por: Fu, Ying, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_stfkbdag0g11uk9m92vip6psav