Cargando…

An innovative small molecule for promoting neuroreparative strategies

In this study, a new regenerative strategy to treat several neurodegenerative diseases is suggested by the use of a multitarget approach induced by our small molecule, MC111. Considering the importance of P-gp and BCRP expression on stem cell differentiation and the involvement of TLR4 on neurodegen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Colabufo, Nicola Antonio, Contino, Marialessandra, Cantore, Mariangela, Berardi, Francesco, Perrone, Roberto, Tonazzi, Annamaria, Console, Lara, Panaro, Maria Antonietta, Savolainen, Heli, Luurtsema, Gert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078125/ https://www.ncbi.nlm.nih.gov/pubmed/35542423 http://dx.doi.org/10.1039/c7ra11812k

Ejemplares similares

Small and Innovative Molecules as New Strategy to Revert MDR
por: Zinzi, Laura, et al.
Publicado: (2014)

Receptor-Drug Interaction: Europium Employment for Studying the Biochemical Pathway of G-Protein-Coupled Receptor Activation
por: Antonio, Colabufo Nicola, et al.
Publicado: (2007)

ABC transporters in CSCs membranes as a novel target for treating tumor relapse
por: Zinzi, Laura, et al.
Publicado: (2014)

Why PB28 Could Be a Covid 2019 Game Changer?
por: Colabufo, Nicola Antonio, et al.
Publicado: (2020)

Comparison of In Vitro Assays in Selecting Radiotracers for In Vivo P-Glycoprotein PET Imaging
por: Raaphorst, Renske M., et al.
Publicado: (2017)

PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships
por: Abate, Carmen, et al.
Publicado: (2020)

Editorial: The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation
por: Contino, Marialessandra, et al.
Publicado: (2017)

Perspectives on neuroreparative therapies for treating multiple sclerosis
por: Xiao, Junhua
Publicado: (2015)

Editorial: Neurodegeneration, cell signaling and neuroreparative strategies
por: Vaz, Ana Rita, et al.
Publicado: (2022)

Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis
por: Medina-Rodríguez, Eva María, et al.
Publicado: (2017)

Characterization of Exosomal SLC22A5 (OCTN2) carnitine transporter
por: Console, Lara, et al.
Publicado: (2018)

The Mitochondrial Carnitine Acyl-carnitine Carrier (SLC25A20): Molecular Mechanisms of Transport, Role in Redox Sensing and Interaction with Drugs
por: Tonazzi, Annamaria, et al.
Publicado: (2021)

Inhibition of the Mitochondrial Carnitine/Acylcarnitine Carrier by Itaconate through Irreversible Binding to Cysteine 136: Possible Pathophysiological Implications
por: Giangregorio, Nicola, et al.
Publicado: (2023)

Glutamate Scavenging as a Neuroreparative Strategy in Ischemic Stroke
por: Kaplan-Arabaci, Oykum, et al.
Publicado: (2022)

The Link Between the Mitochondrial Fatty Acid Oxidation Derangement and Kidney Injury
por: Console, Lara, et al.
Publicado: (2020)

Editorial: Neurodegeneration, cell signaling and neuroreparative strategies, Volume II
por: Vaz, Ana Rita, et al.
Publicado: (2023)

Small-animal PET evaluation of [(11)C]MC113 as a PET tracer for P-glycoprotein
por: Mairinger, Severin, et al.
Publicado: (2010)

Characterization of a Novel Mitochondrial Ascorbate Transporter From Rat Liver and Potato Mitochondria
por: Scalera, Vito, et al.
Publicado: (2018)

Effect of Copper on the Mitochondrial Carnitine/Acylcarnitine Carrier Via Interaction with Cys136 and Cys155. Possible Implications in Pathophysiology
por: Giangregorio, Nicola, et al.
Publicado: (2020)

Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine
por: Gualdani, Roberta, et al.
Publicado: (2015)

Automated synthesis, preclinical toxicity, and radiation dosimetry of [(18)F]MC225 for clinical use: a tracer for measuring P-glycoprotein function at the blood-brain barrier
por: Toyohara, Jun, et al.
Publicado: (2020)

The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line
por: Pagliarulo, Vincenzo, et al.
Publicado: (2013)

Carnitine Traffic in Cells. Link With Cancer
por: Console, Lara, et al.
Publicado: (2020)

Overcoming Multidrug Resistance (MDR): Design, Biological Evaluation and Molecular Modelling Studies of 2,4‐Substituted Quinazoline Derivatives
por: Braconi, Laura, et al.
Publicado: (2022)

COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent
por: Menéndez, Sebastián García, et al.
Publicado: (2022)

miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives
por: Gisel, Andreas, et al.
Publicado: (2014)

6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers
por: Braconi, Laura, et al.
Publicado: (2020)

N-glycosylation is crucial for trafficking and stability of SLC3A2 (CD98)
por: Console, Lara, et al.
Publicado: (2022)

New Strategies to Overcome Resistance to Chemotherapy and Immune System in Cancer
por: Riganti, Chiara, et al.
Publicado: (2019)

Editorial: The Canonical and Non-Canonical Endocannabinoid System as a Target in Cancer and Acute and Chronic Pain
por: Contino, Marialessandra, et al.
Publicado: (2020)

Editorial: Molecular modulators of GPCRs signal transduction
por: Vrecl, Milka, et al.
Publicado: (2023)

In Vivo Induction of P-Glycoprotein Function can be Measured with [(18)F]MC225 and PET
por: García-Varela, Lara, et al.
Publicado: (2021)

Proteoliposomes as Tool for Assaying Membrane Transporter Functions and Interactions with Xenobiotics
por: Scalise, Mariafrancesca, et al.
Publicado: (2013)

Multi-Target Directed Ligands (MTDLs) Binding the σ(1) Receptor as Promising Therapeutics: State of the Art and Perspectives
por: Abatematteo, Francesca Serena, et al.
Publicado: (2021)

Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H(2)O(2)- and Aβ(1-42)-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells
por: de Matos, Ana M., et al.
Publicado: (2019)

Molecular Mechanism of Inhibition of the Mitochondrial Carnitine/Acylcarnitine Transporter by Omeprazole Revealed by Proteoliposome Assay, Mutagenesis and Bioinformatics
por: Tonazzi, Annamaria, et al.
Publicado: (2013)

Pharmacokinetic Modeling of (R)-[(11)C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates
por: García-Varela, Lara, et al.
Publicado: (2020)

Pharmacokinetic Modeling of [(18)F]MC225 for Quantification of the P-Glycoprotein Function at the Blood–Brain Barrier in Non-Human Primates with PET
por: García-Varela, Lara, et al.
Publicado: (2020)

MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor
por: Riganti, Chiara, et al.
Publicado: (2020)

Head-to-head comparison of (R)-[(11)C]verapamil and [(18)F]MC225 in non-human primates, tracers for measuring P-glycoprotein function
por: García-Varela, Lara, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qno2e6k3k197ile8umg5ooo59o