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SKLB023 hinders renal interstitial fibrosis in obstructive nephropathy by interfering TGF-β1/Smad3 signaling

Renal fibrosis is the principal process underlying the progression of chronic kidney disease to end-stage renal disease. It is a relatively uniform response involving glomerulosclerosis, tubulointerstitial fibrosis and changes in renal vasculature. A considerable number of studies have confirmed tha...

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Detalles Bibliográficos
Autores principales: Feng, Yanhuan, Xu, Jun, Guo, Fan, Huang, Rongshuang, Shi, Min, Li, Lingzhi, Ma, Liang, Fu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078199/
https://www.ncbi.nlm.nih.gov/pubmed/35539579
http://dx.doi.org/10.1039/c8ra00018b