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Detection of biomolecules in dielectric modulated double metal below ferroelectric layer FET with improved sensitivity

In this work, we examined the double metal below ferroelectric layer FET that is double metal below negative capacitance field-effect transistor (DM-below-NCFET) for biosensing application and change in nanocavity gap with biomolecules as protein, [Formula: see text] (cholesterol oxidase), streptavi...

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Autores principales: Pathak, Yash, Malhotra, Bansi Dhar, Chaujar, Rishu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078211/
http://dx.doi.org/10.1007/s10854-022-08290-x
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author Pathak, Yash
Malhotra, Bansi Dhar
Chaujar, Rishu
author_facet Pathak, Yash
Malhotra, Bansi Dhar
Chaujar, Rishu
author_sort Pathak, Yash
collection PubMed
description In this work, we examined the double metal below ferroelectric layer FET that is double metal below negative capacitance field-effect transistor (DM-below-NCFET) for biosensing application and change in nanocavity gap with biomolecules as protein, [Formula: see text] (cholesterol oxidase), streptavidin, and uricase. For measuring the electrical characteristic and neutral biosensing such as threshold voltage, switching ratio ([Formula: see text] ) of the device which is higher than one without molecules by 1.52 times, sensitivity of protein enhanced by 1.11 over without biomolecule, limit of detection of protein is higher by 1.012 times over without molecule, shift in potential have been researched for cavity length 10 nm. The biosensor indicated improved sensitivity for biomolecules with the rise in their dielectric parameter. Moreover, modulation of the length of the gap of cavity was too examined, exposing that its increment (from 8 to 12 nm) altogether upgraded the sensitivity of the proposed biosensor. Visual TCAD (Technology Computer-Aided Design) software is used for simulating all results. In general, the consequences of this examination represent that such DM-below-NCFET biosensors can display extreme sensitivity (1.11) at small drain voltage (0.4 V), empowering their utilization for biosensor applications to analyze different infections which involve low power, extreme density, and enhanced speed.
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spelling pubmed-90782112022-05-09 Detection of biomolecules in dielectric modulated double metal below ferroelectric layer FET with improved sensitivity Pathak, Yash Malhotra, Bansi Dhar Chaujar, Rishu J Mater Sci: Mater Electron Article In this work, we examined the double metal below ferroelectric layer FET that is double metal below negative capacitance field-effect transistor (DM-below-NCFET) for biosensing application and change in nanocavity gap with biomolecules as protein, [Formula: see text] (cholesterol oxidase), streptavidin, and uricase. For measuring the electrical characteristic and neutral biosensing such as threshold voltage, switching ratio ([Formula: see text] ) of the device which is higher than one without molecules by 1.52 times, sensitivity of protein enhanced by 1.11 over without biomolecule, limit of detection of protein is higher by 1.012 times over without molecule, shift in potential have been researched for cavity length 10 nm. The biosensor indicated improved sensitivity for biomolecules with the rise in their dielectric parameter. Moreover, modulation of the length of the gap of cavity was too examined, exposing that its increment (from 8 to 12 nm) altogether upgraded the sensitivity of the proposed biosensor. Visual TCAD (Technology Computer-Aided Design) software is used for simulating all results. In general, the consequences of this examination represent that such DM-below-NCFET biosensors can display extreme sensitivity (1.11) at small drain voltage (0.4 V), empowering their utilization for biosensor applications to analyze different infections which involve low power, extreme density, and enhanced speed. Springer US 2022-05-07 2022 /pmc/articles/PMC9078211/ http://dx.doi.org/10.1007/s10854-022-08290-x Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Pathak, Yash
Malhotra, Bansi Dhar
Chaujar, Rishu
Detection of biomolecules in dielectric modulated double metal below ferroelectric layer FET with improved sensitivity
title Detection of biomolecules in dielectric modulated double metal below ferroelectric layer FET with improved sensitivity
title_full Detection of biomolecules in dielectric modulated double metal below ferroelectric layer FET with improved sensitivity
title_fullStr Detection of biomolecules in dielectric modulated double metal below ferroelectric layer FET with improved sensitivity
title_full_unstemmed Detection of biomolecules in dielectric modulated double metal below ferroelectric layer FET with improved sensitivity
title_short Detection of biomolecules in dielectric modulated double metal below ferroelectric layer FET with improved sensitivity
title_sort detection of biomolecules in dielectric modulated double metal below ferroelectric layer fet with improved sensitivity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078211/
http://dx.doi.org/10.1007/s10854-022-08290-x
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