A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers

We designed and explored self-assembled gold nanoparticles (SAGNPs) by introducing dithiol modified polyethylene glycol (PEG) for internanoparticle cross-linking. SAGNPs could enhance uptake into cancer cells and be disintegrated by glutathione (GSH) to achieve tumor microenvironment-activated biode...

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Detalles Bibliográficos
Autores principales: Fu, Yingjie, Feng, Qishuai, Shen, Yajing, Chen, Mengwei, Xu, Chang, Cheng, Yu, Zhou, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078271/
https://www.ncbi.nlm.nih.gov/pubmed/35539587
http://dx.doi.org/10.1039/c7ra12735a
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author Fu, Yingjie
Feng, Qishuai
Shen, Yajing
Chen, Mengwei
Xu, Chang
Cheng, Yu
Zhou, Xiang
author_facet Fu, Yingjie
Feng, Qishuai
Shen, Yajing
Chen, Mengwei
Xu, Chang
Cheng, Yu
Zhou, Xiang
author_sort Fu, Yingjie
collection PubMed
description We designed and explored self-assembled gold nanoparticles (SAGNPs) by introducing dithiol modified polyethylene glycol (PEG) for internanoparticle cross-linking. SAGNPs could enhance uptake into cancer cells and be disintegrated by glutathione (GSH) to achieve tumor microenvironment-activated biodegradation. This assembled structure improved the photothermal effect compared to single gold nanospheres.
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spelling pubmed-90782712022-05-09 A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers Fu, Yingjie Feng, Qishuai Shen, Yajing Chen, Mengwei Xu, Chang Cheng, Yu Zhou, Xiang RSC Adv Chemistry We designed and explored self-assembled gold nanoparticles (SAGNPs) by introducing dithiol modified polyethylene glycol (PEG) for internanoparticle cross-linking. SAGNPs could enhance uptake into cancer cells and be disintegrated by glutathione (GSH) to achieve tumor microenvironment-activated biodegradation. This assembled structure improved the photothermal effect compared to single gold nanospheres. The Royal Society of Chemistry 2018-02-07 /pmc/articles/PMC9078271/ /pubmed/35539587 http://dx.doi.org/10.1039/c7ra12735a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Fu, Yingjie
Feng, Qishuai
Shen, Yajing
Chen, Mengwei
Xu, Chang
Cheng, Yu
Zhou, Xiang
A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers
title A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers
title_full A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers
title_fullStr A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers
title_full_unstemmed A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers
title_short A feasible strategy for self-assembly of gold nanoparticles via dithiol-PEG for photothermal therapy of cancers
title_sort feasible strategy for self-assembly of gold nanoparticles via dithiol-peg for photothermal therapy of cancers
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078271/
https://www.ncbi.nlm.nih.gov/pubmed/35539587
http://dx.doi.org/10.1039/c7ra12735a
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