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Novel Liposomal Rolipram Formulation for Clinical Application to Reduce Emesis

INTRODUCTION: The phosphodiesterase 4 (PDE4) inhibitor, rolipram, has beneficial effects on tissue inflammation, injury and fibrosis, including in the liver. Since rolipram elicits significant CNS side-effects in humans (ie, nausea and emesis), our group developed a fusogenic lipid vesicle (FLV) dru...

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Detalles Bibliográficos
Autores principales:	Gobejishvili, Leila, Rodriguez, Walter E, Bauer, Philip, Wang, Yali, Soni, Chirag, Lydic, Todd, Barve, Shirish, McClain, Craig, Maldonado, Claudio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078351/ https://www.ncbi.nlm.nih.gov/pubmed/35535222 http://dx.doi.org/10.2147/DDDT.S355796

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