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Fluorescence enhancement of gold nanoclusters via Zn doping for biomedical applications
Gold nanoclusters (NCs) have been widely used in bioimaging and cancer therapy due to their unique electronic structures and tunable luminescence. However, their weak fluorescence prevents potential biomedical application, and thus it is necessary to develop an effective route to enhance the fluores...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078413/ https://www.ncbi.nlm.nih.gov/pubmed/35539114 http://dx.doi.org/10.1039/c7ra13072d |
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author | Qiao, Yanqing Liu, Ying Liu, Haixia Li, Yonghui Long, Wei Wang, Junying Mu, Xiaoyu Chen, Jing Liu, Haile Bai, Xueting Liu, Lingfang Sun, Yuan-Ming Liu, Qiang Guo, Meili Zhang, Xiao-Dong |
author_facet | Qiao, Yanqing Liu, Ying Liu, Haixia Li, Yonghui Long, Wei Wang, Junying Mu, Xiaoyu Chen, Jing Liu, Haile Bai, Xueting Liu, Lingfang Sun, Yuan-Ming Liu, Qiang Guo, Meili Zhang, Xiao-Dong |
author_sort | Qiao, Yanqing |
collection | PubMed |
description | Gold nanoclusters (NCs) have been widely used in bioimaging and cancer therapy due to their unique electronic structures and tunable luminescence. However, their weak fluorescence prevents potential biomedical application, and thus it is necessary to develop an effective route to enhance the fluorescence of gold NCs. In this work, we report the fluorescence enhancement of ultrasmall GSH-protected Au NCs by Zn atom doping. The fluorescence signal of Zn-doped Au NCs shows approximately 5-fold enhancement compared to pure Au NCs. Density functional theory (DFT) calculation shows that Zn doping can enhance the electronic states of the highest occupied molecular orbital (HOMO), leading to enhancement of visible optical transitions. In vitro experiments show that AuZn alloy NCs can enhance the cancer radiotherapy via producing reactive oxygen species (ROS) and don't cause significant cytotoxicity. In vivo imaging indicates AuZn alloy NCs have significant passive targeting capability with high tumor uptake. Moreover, nearly 80% of GSH-protected AuZn alloy NCs can be rapidly eliminated via urine excretion. |
format | Online Article Text |
id | pubmed-9078413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90784132022-05-09 Fluorescence enhancement of gold nanoclusters via Zn doping for biomedical applications Qiao, Yanqing Liu, Ying Liu, Haixia Li, Yonghui Long, Wei Wang, Junying Mu, Xiaoyu Chen, Jing Liu, Haile Bai, Xueting Liu, Lingfang Sun, Yuan-Ming Liu, Qiang Guo, Meili Zhang, Xiao-Dong RSC Adv Chemistry Gold nanoclusters (NCs) have been widely used in bioimaging and cancer therapy due to their unique electronic structures and tunable luminescence. However, their weak fluorescence prevents potential biomedical application, and thus it is necessary to develop an effective route to enhance the fluorescence of gold NCs. In this work, we report the fluorescence enhancement of ultrasmall GSH-protected Au NCs by Zn atom doping. The fluorescence signal of Zn-doped Au NCs shows approximately 5-fold enhancement compared to pure Au NCs. Density functional theory (DFT) calculation shows that Zn doping can enhance the electronic states of the highest occupied molecular orbital (HOMO), leading to enhancement of visible optical transitions. In vitro experiments show that AuZn alloy NCs can enhance the cancer radiotherapy via producing reactive oxygen species (ROS) and don't cause significant cytotoxicity. In vivo imaging indicates AuZn alloy NCs have significant passive targeting capability with high tumor uptake. Moreover, nearly 80% of GSH-protected AuZn alloy NCs can be rapidly eliminated via urine excretion. The Royal Society of Chemistry 2018-02-15 /pmc/articles/PMC9078413/ /pubmed/35539114 http://dx.doi.org/10.1039/c7ra13072d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Qiao, Yanqing Liu, Ying Liu, Haixia Li, Yonghui Long, Wei Wang, Junying Mu, Xiaoyu Chen, Jing Liu, Haile Bai, Xueting Liu, Lingfang Sun, Yuan-Ming Liu, Qiang Guo, Meili Zhang, Xiao-Dong Fluorescence enhancement of gold nanoclusters via Zn doping for biomedical applications |
title | Fluorescence enhancement of gold nanoclusters via Zn doping for biomedical applications |
title_full | Fluorescence enhancement of gold nanoclusters via Zn doping for biomedical applications |
title_fullStr | Fluorescence enhancement of gold nanoclusters via Zn doping for biomedical applications |
title_full_unstemmed | Fluorescence enhancement of gold nanoclusters via Zn doping for biomedical applications |
title_short | Fluorescence enhancement of gold nanoclusters via Zn doping for biomedical applications |
title_sort | fluorescence enhancement of gold nanoclusters via zn doping for biomedical applications |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078413/ https://www.ncbi.nlm.nih.gov/pubmed/35539114 http://dx.doi.org/10.1039/c7ra13072d |
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