Adventures in radiosynthesis of clinical grade [(68)Ga]Ga-DOTA-Siglec-9

We finally managed to establish a protocol for generating Good Manufacturing Practice (GMP)-grade gallium-68-labelled 1,4,7,0-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugated sialic acid-binding immunoglobulin-like lectin 9 motif containing peptide ([(68)Ga]Ga-DOTA-Siglec-9), the first rad...

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Detalles Bibliográficos
Autores principales: Käkelä, Meeri, Luoto, Pauliina, Viljanen, Tapio, Virtanen, Helena, Liljenbäck, Heidi, Jalkanen, Sirpa, Knuuti, Juhani, Roivainen, Anne, Li, Xiang-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078465/
https://www.ncbi.nlm.nih.gov/pubmed/35542034
http://dx.doi.org/10.1039/c7ra12423f
Descripción
Sumario:We finally managed to establish a protocol for generating Good Manufacturing Practice (GMP)-grade gallium-68-labelled 1,4,7,0-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugated sialic acid-binding immunoglobulin-like lectin 9 motif containing peptide ([(68)Ga]Ga-DOTA-Siglec-9), the first radiopharmaceutical for positron emission tomography imaging of vascular adhesion protein 1.

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