Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis

Two new cycloartane triterpenes, cimyunnin E (1), containing a unique oxaspiro[4.4]nonanedione moiety based on rings D and E, together with cimicifine B (2), a 25,26,27-trinortriterpene featuring a pyridine ring E, were purified from the fruits of Cimicifuga yunnanensis. Their structures were elucid...

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Detalles Bibliográficos
Autores principales: Nian, Yin, Lu, Ni-Hong, Liu, Xiao-Ling, Li, Da-Shan, Zhou, Lin, Qiu, Ming-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078504/
https://www.ncbi.nlm.nih.gov/pubmed/35539105
http://dx.doi.org/10.1039/c8ra00291f
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author Nian, Yin
Lu, Ni-Hong
Liu, Xiao-Ling
Li, Da-Shan
Zhou, Lin
Qiu, Ming-Hua
author_facet Nian, Yin
Lu, Ni-Hong
Liu, Xiao-Ling
Li, Da-Shan
Zhou, Lin
Qiu, Ming-Hua
author_sort Nian, Yin
collection PubMed
description Two new cycloartane triterpenes, cimyunnin E (1), containing a unique oxaspiro[4.4]nonanedione moiety based on rings D and E, together with cimicifine B (2), a 25,26,27-trinortriterpene featuring a pyridine ring E, were purified from the fruits of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic methods and ECD (electronic circular dichroism calculations). Compounds 1 and 2 showed significant acetylcholinesterase (AChE) inhibition with IC(50) values of 1.58 and 3.87 μM, respectively. In addition, they noticeably enhanced the neurite outgrowth of nerve growth factor (NGF) mediated PC12 cells at a concentration of 10 μM.
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spelling pubmed-90785042022-05-09 Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis Nian, Yin Lu, Ni-Hong Liu, Xiao-Ling Li, Da-Shan Zhou, Lin Qiu, Ming-Hua RSC Adv Chemistry Two new cycloartane triterpenes, cimyunnin E (1), containing a unique oxaspiro[4.4]nonanedione moiety based on rings D and E, together with cimicifine B (2), a 25,26,27-trinortriterpene featuring a pyridine ring E, were purified from the fruits of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic methods and ECD (electronic circular dichroism calculations). Compounds 1 and 2 showed significant acetylcholinesterase (AChE) inhibition with IC(50) values of 1.58 and 3.87 μM, respectively. In addition, they noticeably enhanced the neurite outgrowth of nerve growth factor (NGF) mediated PC12 cells at a concentration of 10 μM. The Royal Society of Chemistry 2018-02-19 /pmc/articles/PMC9078504/ /pubmed/35539105 http://dx.doi.org/10.1039/c8ra00291f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Nian, Yin
Lu, Ni-Hong
Liu, Xiao-Ling
Li, Da-Shan
Zhou, Lin
Qiu, Ming-Hua
Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis
title Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis
title_full Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis
title_fullStr Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis
title_full_unstemmed Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis
title_short Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis
title_sort antiacetylcholinesterase triterpenes from the fruits of cimicifuga yunnanensis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078504/
https://www.ncbi.nlm.nih.gov/pubmed/35539105
http://dx.doi.org/10.1039/c8ra00291f
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