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Fabrication of macroporous reduced graphene oxide composite aerogels reinforced with chitosan for high bilirubin adsorption

Numerous adsorbents have been reported for the removal of bilirubin, which is a well-known endogenous toxin. Three-dimensional graphene sponges and aerogels have been fully studied in the adsorption field but little in hemoperfusion especially for bilirubin adsorption. In this study, macroporous red...

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Autores principales: Li, Zhentao, Song, Xi, Cui, Siyuan, Jiao, Yanpeng, Zhou, Changren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078524/
https://www.ncbi.nlm.nih.gov/pubmed/35542023
http://dx.doi.org/10.1039/c8ra00358k
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author Li, Zhentao
Song, Xi
Cui, Siyuan
Jiao, Yanpeng
Zhou, Changren
author_facet Li, Zhentao
Song, Xi
Cui, Siyuan
Jiao, Yanpeng
Zhou, Changren
author_sort Li, Zhentao
collection PubMed
description Numerous adsorbents have been reported for the removal of bilirubin, which is a well-known endogenous toxin. Three-dimensional graphene sponges and aerogels have been fully studied in the adsorption field but little in hemoperfusion especially for bilirubin adsorption. In this study, macroporous reduced graphene oxide (GO) aerogels were fabricated by a chemical reduction method. Besides, chitosan was introduced in the aerogels during the reduction process to improve their mechanical properties. The graphene oxide composite aerogels reinforced with chitosan (rGO/CS) were investigated using scanning electron microscopy (SEM), Fourier Transform Infrared Spectrometry (FTIR), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) and Brunauer–Emmett–Teller (BET). Furthermore, the mechanical properties test showed the reinforced mechanical strength of the rGO/CS aerogels. The adsorption performance of the aerogels for bilirubin was studied in detail, showing a high adsorption capacity (458.9 mg g(−1)) and a fast adsorption rate. Moreover, the low hemolysis ratio and negligible anticoagulant activity of rGO/CS aerogels suggested good blood compatibility. The mesoporous structure of the aerogels can provide good mechanical strength, and the macroporous structure of the rGO/CS aerogels shows a good adsorption capacity, which would have potential applications in bilirubin adsorption.
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spelling pubmed-90785242022-05-09 Fabrication of macroporous reduced graphene oxide composite aerogels reinforced with chitosan for high bilirubin adsorption Li, Zhentao Song, Xi Cui, Siyuan Jiao, Yanpeng Zhou, Changren RSC Adv Chemistry Numerous adsorbents have been reported for the removal of bilirubin, which is a well-known endogenous toxin. Three-dimensional graphene sponges and aerogels have been fully studied in the adsorption field but little in hemoperfusion especially for bilirubin adsorption. In this study, macroporous reduced graphene oxide (GO) aerogels were fabricated by a chemical reduction method. Besides, chitosan was introduced in the aerogels during the reduction process to improve their mechanical properties. The graphene oxide composite aerogels reinforced with chitosan (rGO/CS) were investigated using scanning electron microscopy (SEM), Fourier Transform Infrared Spectrometry (FTIR), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) and Brunauer–Emmett–Teller (BET). Furthermore, the mechanical properties test showed the reinforced mechanical strength of the rGO/CS aerogels. The adsorption performance of the aerogels for bilirubin was studied in detail, showing a high adsorption capacity (458.9 mg g(−1)) and a fast adsorption rate. Moreover, the low hemolysis ratio and negligible anticoagulant activity of rGO/CS aerogels suggested good blood compatibility. The mesoporous structure of the aerogels can provide good mechanical strength, and the macroporous structure of the rGO/CS aerogels shows a good adsorption capacity, which would have potential applications in bilirubin adsorption. The Royal Society of Chemistry 2018-02-22 /pmc/articles/PMC9078524/ /pubmed/35542023 http://dx.doi.org/10.1039/c8ra00358k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Li, Zhentao
Song, Xi
Cui, Siyuan
Jiao, Yanpeng
Zhou, Changren
Fabrication of macroporous reduced graphene oxide composite aerogels reinforced with chitosan for high bilirubin adsorption
title Fabrication of macroporous reduced graphene oxide composite aerogels reinforced with chitosan for high bilirubin adsorption
title_full Fabrication of macroporous reduced graphene oxide composite aerogels reinforced with chitosan for high bilirubin adsorption
title_fullStr Fabrication of macroporous reduced graphene oxide composite aerogels reinforced with chitosan for high bilirubin adsorption
title_full_unstemmed Fabrication of macroporous reduced graphene oxide composite aerogels reinforced with chitosan for high bilirubin adsorption
title_short Fabrication of macroporous reduced graphene oxide composite aerogels reinforced with chitosan for high bilirubin adsorption
title_sort fabrication of macroporous reduced graphene oxide composite aerogels reinforced with chitosan for high bilirubin adsorption
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078524/
https://www.ncbi.nlm.nih.gov/pubmed/35542023
http://dx.doi.org/10.1039/c8ra00358k
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AT jiaoyanpeng fabricationofmacroporousreducedgrapheneoxidecompositeaerogelsreinforcedwithchitosanforhighbilirubinadsorption
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