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Prediction of the targets of the main components in blood after oral administration of Xanthii Fructus: a network pharmacology study

Xanthii Fructus (XF), a famous traditional Chinese medicine (TCM), has been widely used in the treatment of rhinitis and other diseases. However, the targets of the main XF components found in the blood after oral administration of XF extract are still unclear. In the current study, a feasible syste...

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Detalles Bibliográficos
Autores principales: Zhuang, Yanshuang, Qin, Kunming, Yang, Bing, Liu, Xiao, Cai, Baochang, Cai, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078587/
https://www.ncbi.nlm.nih.gov/pubmed/35539827
http://dx.doi.org/10.1039/c8ra00186c
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author Zhuang, Yanshuang
Qin, Kunming
Yang, Bing
Liu, Xiao
Cai, Baochang
Cai, Hao
author_facet Zhuang, Yanshuang
Qin, Kunming
Yang, Bing
Liu, Xiao
Cai, Baochang
Cai, Hao
author_sort Zhuang, Yanshuang
collection PubMed
description Xanthii Fructus (XF), a famous traditional Chinese medicine (TCM), has been widely used in the treatment of rhinitis and other diseases. However, the targets of the main XF components found in the blood after oral administration of XF extract are still unclear. In the current study, a feasible systems pharmacology method was developed to predict these targets. In accordance with our previous research, XF components were selected including cleomiscosin A, myristic acid, succinic acid, xanthosine, sitostenone, emodin, apigenin, and chrysophanol. Three components, namely emodin, apigenin, and chrysophanol, failed to be detected with target proteins, thus the other five components, namely cleomiscosin A, myristic acid, succinic acid, xanthosine and sitostenone, were eventually chosen for further systematic analysis. Ninety-nine target proteins and fifty-two pathways were found after a series of analyses. The frequency of some target proteins was much higher than that of others; high frequencies were obtained for P15086, P07360, P07195, MAOM_HUMAN (P23368), P35558, P35520, ACE_HUMAN (P12821), C1S_HUMAN (P09871), PH4H_HUMAN (P00439), FPPS_HUMAN (P14324), P50613, P12724, IMPA1_HUMAN (P29218), HXK1_HUMAN (P19367), P14061, and MCR_HUMAN (P08235). The frequency of eight pathways was also high, including Generic Transcription Pathway, RNA Polymerase II Transcription, Metabolism, Metabolism of steroids, Gene expression (Transcription), Cellular responses to stress, Platelet activation, signaling and aggregation, Signaling by Receptor Tyrosine Kinases, and Cellular Senescence. This study identified a common pathway – the Metabolism pathway – for all five XF components. We successfully developed a network pharmacology method to predict the potential targets of the main XF components absorbed in serum after oral administration of XF extract.
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spelling pubmed-90785872022-05-09 Prediction of the targets of the main components in blood after oral administration of Xanthii Fructus: a network pharmacology study Zhuang, Yanshuang Qin, Kunming Yang, Bing Liu, Xiao Cai, Baochang Cai, Hao RSC Adv Chemistry Xanthii Fructus (XF), a famous traditional Chinese medicine (TCM), has been widely used in the treatment of rhinitis and other diseases. However, the targets of the main XF components found in the blood after oral administration of XF extract are still unclear. In the current study, a feasible systems pharmacology method was developed to predict these targets. In accordance with our previous research, XF components were selected including cleomiscosin A, myristic acid, succinic acid, xanthosine, sitostenone, emodin, apigenin, and chrysophanol. Three components, namely emodin, apigenin, and chrysophanol, failed to be detected with target proteins, thus the other five components, namely cleomiscosin A, myristic acid, succinic acid, xanthosine and sitostenone, were eventually chosen for further systematic analysis. Ninety-nine target proteins and fifty-two pathways were found after a series of analyses. The frequency of some target proteins was much higher than that of others; high frequencies were obtained for P15086, P07360, P07195, MAOM_HUMAN (P23368), P35558, P35520, ACE_HUMAN (P12821), C1S_HUMAN (P09871), PH4H_HUMAN (P00439), FPPS_HUMAN (P14324), P50613, P12724, IMPA1_HUMAN (P29218), HXK1_HUMAN (P19367), P14061, and MCR_HUMAN (P08235). The frequency of eight pathways was also high, including Generic Transcription Pathway, RNA Polymerase II Transcription, Metabolism, Metabolism of steroids, Gene expression (Transcription), Cellular responses to stress, Platelet activation, signaling and aggregation, Signaling by Receptor Tyrosine Kinases, and Cellular Senescence. This study identified a common pathway – the Metabolism pathway – for all five XF components. We successfully developed a network pharmacology method to predict the potential targets of the main XF components absorbed in serum after oral administration of XF extract. The Royal Society of Chemistry 2018-02-27 /pmc/articles/PMC9078587/ /pubmed/35539827 http://dx.doi.org/10.1039/c8ra00186c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Zhuang, Yanshuang
Qin, Kunming
Yang, Bing
Liu, Xiao
Cai, Baochang
Cai, Hao
Prediction of the targets of the main components in blood after oral administration of Xanthii Fructus: a network pharmacology study
title Prediction of the targets of the main components in blood after oral administration of Xanthii Fructus: a network pharmacology study
title_full Prediction of the targets of the main components in blood after oral administration of Xanthii Fructus: a network pharmacology study
title_fullStr Prediction of the targets of the main components in blood after oral administration of Xanthii Fructus: a network pharmacology study
title_full_unstemmed Prediction of the targets of the main components in blood after oral administration of Xanthii Fructus: a network pharmacology study
title_short Prediction of the targets of the main components in blood after oral administration of Xanthii Fructus: a network pharmacology study
title_sort prediction of the targets of the main components in blood after oral administration of xanthii fructus: a network pharmacology study
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078587/
https://www.ncbi.nlm.nih.gov/pubmed/35539827
http://dx.doi.org/10.1039/c8ra00186c
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