Sodium periodate/TEMPO as a selective and efficient system for amine oxidation

A new metal-free protocol for promoting oxidation of amines in aqueous-organic medium was developed. NaIO(4) and TEMPO as the catalyst emerged as the most efficient and selective system for oxidation of differently substituted benzyl amines to the corresponding benzaldehydes without overoxidation. U...

Descripción completa

Detalles Bibliográficos
Autores principales: Galletti, P., Martelli, G., Prandini, G., Colucci, C., Giacomini, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078700/
https://www.ncbi.nlm.nih.gov/pubmed/35540807
http://dx.doi.org/10.1039/c8ra01365a
Descripción
Sumario:A new metal-free protocol for promoting oxidation of amines in aqueous-organic medium was developed. NaIO(4) and TEMPO as the catalyst emerged as the most efficient and selective system for oxidation of differently substituted benzyl amines to the corresponding benzaldehydes without overoxidation. Unsymmetrical secondary amines underwent selective oxidation only at the benzylic position thus realising an oxidative deprotection of a benzylic group with an easy amine recovery.

Ejemplares similares