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Preparation and characterization of an electrospun colon-specific delivery system for salmon calcitonin
A novel electrospun colon-specific delivery system for salmon calcitonin (SCT) was developed to improve its stability and bioavailability. Firstly, the pectin-coated SCT liposomes were prepared by film dispersion method and then a liposomes/sodium alginate/polyvinyl alcohol fiber mat was fabricated...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078742/ https://www.ncbi.nlm.nih.gov/pubmed/35540827 http://dx.doi.org/10.1039/c8ra00385h |
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author | Li, Chen Wei, Yun-shan Wen, Peng Feng, Kun Zong, Min-hua Wu, Hong |
author_facet | Li, Chen Wei, Yun-shan Wen, Peng Feng, Kun Zong, Min-hua Wu, Hong |
author_sort | Li, Chen |
collection | PubMed |
description | A novel electrospun colon-specific delivery system for salmon calcitonin (SCT) was developed to improve its stability and bioavailability. Firstly, the pectin-coated SCT liposomes were prepared by film dispersion method and then a liposomes/sodium alginate/polyvinyl alcohol fiber mat was fabricated by electrospining. Scanning electron microscopy analysis indicated that the obtained nanofibers were uniform and smooth with an average diameter of about 350 nm. The release of SCT in different simulated digestive fluids was studied and corresponding release kinetics models were built. It was found that the fiber mat containing pectin-coated SCT liposomes had better stability and colon-specific properties compared with that containing uncoated SCT liposomes and the release of SCT in the colon followed the case II transport mechanism. In addition, there is no significant change in the bioactivity of released SCT measured by ELISA. This study shows that the electrospun colon-specific fiber mat is a potential delivery system for bioactive peptides. |
format | Online Article Text |
id | pubmed-9078742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90787422022-05-09 Preparation and characterization of an electrospun colon-specific delivery system for salmon calcitonin Li, Chen Wei, Yun-shan Wen, Peng Feng, Kun Zong, Min-hua Wu, Hong RSC Adv Chemistry A novel electrospun colon-specific delivery system for salmon calcitonin (SCT) was developed to improve its stability and bioavailability. Firstly, the pectin-coated SCT liposomes were prepared by film dispersion method and then a liposomes/sodium alginate/polyvinyl alcohol fiber mat was fabricated by electrospining. Scanning electron microscopy analysis indicated that the obtained nanofibers were uniform and smooth with an average diameter of about 350 nm. The release of SCT in different simulated digestive fluids was studied and corresponding release kinetics models were built. It was found that the fiber mat containing pectin-coated SCT liposomes had better stability and colon-specific properties compared with that containing uncoated SCT liposomes and the release of SCT in the colon followed the case II transport mechanism. In addition, there is no significant change in the bioactivity of released SCT measured by ELISA. This study shows that the electrospun colon-specific fiber mat is a potential delivery system for bioactive peptides. The Royal Society of Chemistry 2018-03-08 /pmc/articles/PMC9078742/ /pubmed/35540827 http://dx.doi.org/10.1039/c8ra00385h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Li, Chen Wei, Yun-shan Wen, Peng Feng, Kun Zong, Min-hua Wu, Hong Preparation and characterization of an electrospun colon-specific delivery system for salmon calcitonin |
title | Preparation and characterization of an electrospun colon-specific delivery system for salmon calcitonin |
title_full | Preparation and characterization of an electrospun colon-specific delivery system for salmon calcitonin |
title_fullStr | Preparation and characterization of an electrospun colon-specific delivery system for salmon calcitonin |
title_full_unstemmed | Preparation and characterization of an electrospun colon-specific delivery system for salmon calcitonin |
title_short | Preparation and characterization of an electrospun colon-specific delivery system for salmon calcitonin |
title_sort | preparation and characterization of an electrospun colon-specific delivery system for salmon calcitonin |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078742/ https://www.ncbi.nlm.nih.gov/pubmed/35540827 http://dx.doi.org/10.1039/c8ra00385h |
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