Peroxoniobium inhibits leukemia cell growth

A new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy. The complex inhibits the growth of chronic myelogenous leukemia cells with an IC(50) value of 30 μM, in the dark. However, upon exposure to light (365 nm) there is a fiv...

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Detalles Bibliográficos
Autores principales: Pereira-Maia, Elene C., Souza, Ivina P., Nunes, Kelen J. R. C., Castro, Alexandre A., Ramalho, Teodorico C., Steffler, Fernando, Duarte, Helio A., Pacheli, Ana, Chagas, Poliana, Oliveira, Luiz C. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078932/
https://www.ncbi.nlm.nih.gov/pubmed/35540472
http://dx.doi.org/10.1039/c8ra00898a
Descripción
Sumario:A new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy. The complex inhibits the growth of chronic myelogenous leukemia cells with an IC(50) value of 30 μM, in the dark. However, upon exposure to light (365 nm) there is a fivefold increase in the cytotoxic activity. Light radiation activate the complex with the formation of radical species capable of interacting with DNA according to our experimental and theoretical data.

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