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Peroxoniobium inhibits leukemia cell growth
A new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy. The complex inhibits the growth of chronic myelogenous leukemia cells with an IC(50) value of 30 μM, in the dark. However, upon exposure to light (365 nm) there is a fiv...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078932/ https://www.ncbi.nlm.nih.gov/pubmed/35540472 http://dx.doi.org/10.1039/c8ra00898a |
| _version_ | 1784702448399548416 |
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| author | Pereira-Maia, Elene C. Souza, Ivina P. Nunes, Kelen J. R. C. Castro, Alexandre A. Ramalho, Teodorico C. Steffler, Fernando Duarte, Helio A. Pacheli, Ana Chagas, Poliana Oliveira, Luiz C. A. |
| author_facet | Pereira-Maia, Elene C. Souza, Ivina P. Nunes, Kelen J. R. C. Castro, Alexandre A. Ramalho, Teodorico C. Steffler, Fernando Duarte, Helio A. Pacheli, Ana Chagas, Poliana Oliveira, Luiz C. A. |
| author_sort | Pereira-Maia, Elene C. |
| collection | PubMed |
| description | A new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy. The complex inhibits the growth of chronic myelogenous leukemia cells with an IC(50) value of 30 μM, in the dark. However, upon exposure to light (365 nm) there is a fivefold increase in the cytotoxic activity. Light radiation activate the complex with the formation of radical species capable of interacting with DNA according to our experimental and theoretical data. |
| format | Online Article Text |
| id | pubmed-9078932 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | The Royal Society of Chemistry |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-90789322022-05-09 Peroxoniobium inhibits leukemia cell growth Pereira-Maia, Elene C. Souza, Ivina P. Nunes, Kelen J. R. C. Castro, Alexandre A. Ramalho, Teodorico C. Steffler, Fernando Duarte, Helio A. Pacheli, Ana Chagas, Poliana Oliveira, Luiz C. A. RSC Adv Chemistry A new class of polyoxoniobate complex has been synthesized and characterized as a novel anticancer agent for photodynamic therapy. The complex inhibits the growth of chronic myelogenous leukemia cells with an IC(50) value of 30 μM, in the dark. However, upon exposure to light (365 nm) there is a fivefold increase in the cytotoxic activity. Light radiation activate the complex with the formation of radical species capable of interacting with DNA according to our experimental and theoretical data. The Royal Society of Chemistry 2018-03-14 /pmc/articles/PMC9078932/ /pubmed/35540472 http://dx.doi.org/10.1039/c8ra00898a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
| spellingShingle | Chemistry Pereira-Maia, Elene C. Souza, Ivina P. Nunes, Kelen J. R. C. Castro, Alexandre A. Ramalho, Teodorico C. Steffler, Fernando Duarte, Helio A. Pacheli, Ana Chagas, Poliana Oliveira, Luiz C. A. Peroxoniobium inhibits leukemia cell growth |
| title | Peroxoniobium inhibits leukemia cell growth |
| title_full | Peroxoniobium inhibits leukemia cell growth |
| title_fullStr | Peroxoniobium inhibits leukemia cell growth |
| title_full_unstemmed | Peroxoniobium inhibits leukemia cell growth |
| title_short | Peroxoniobium inhibits leukemia cell growth |
| title_sort | peroxoniobium inhibits leukemia cell growth |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078932/ https://www.ncbi.nlm.nih.gov/pubmed/35540472 http://dx.doi.org/10.1039/c8ra00898a |
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