Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation

Mitochondrial dysfunction and oxidative stress-mediated inflammasome activation play critical roles in the pathogenesis of the non-alcoholic fatty liver disease (NAFLD). Non-steroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1), or growth differentiation factor-15 (GDF15), is associated...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Chen, Chaojie, Chen, Jiajun, Sang, Tingting, Peng, He, Lin, Xiaojian, Zhao, Qian, Chen, Shengjia, Eling, Thomas, Wang, Xingya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079118/
https://www.ncbi.nlm.nih.gov/pubmed/35504134
http://dx.doi.org/10.1016/j.redox.2022.102322

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