A novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells

A novel theranostic prodrug was designed and synthesized by conjugating a naphthalimide derivative with vitamin D(2)via a disulfide linker. The prodrug featured a highly selective detection process for glutathione (GSH) and showed a red-shifted fluorescence within 30 min. Notably, it also exhibited...

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Detalles Bibliográficos
Autores principales: Zhang, Hengrui, Fang, Zhijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079131/
https://www.ncbi.nlm.nih.gov/pubmed/35542771
http://dx.doi.org/10.1039/c8ra00271a
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author Zhang, Hengrui
Fang, Zhijie
author_facet Zhang, Hengrui
Fang, Zhijie
author_sort Zhang, Hengrui
collection PubMed
description A novel theranostic prodrug was designed and synthesized by conjugating a naphthalimide derivative with vitamin D(2)via a disulfide linker. The prodrug featured a highly selective detection process for glutathione (GSH) and showed a red-shifted fluorescence within 30 min. Notably, it also exhibited antitumor activity similar to vitamin D(2) and could be monitored by cellular imaging.
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spelling pubmed-90791312022-05-09 A novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells Zhang, Hengrui Fang, Zhijie RSC Adv Chemistry A novel theranostic prodrug was designed and synthesized by conjugating a naphthalimide derivative with vitamin D(2)via a disulfide linker. The prodrug featured a highly selective detection process for glutathione (GSH) and showed a red-shifted fluorescence within 30 min. Notably, it also exhibited antitumor activity similar to vitamin D(2) and could be monitored by cellular imaging. The Royal Society of Chemistry 2018-03-22 /pmc/articles/PMC9079131/ /pubmed/35542771 http://dx.doi.org/10.1039/c8ra00271a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhang, Hengrui
Fang, Zhijie
A novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells
title A novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells
title_full A novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells
title_fullStr A novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells
title_full_unstemmed A novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells
title_short A novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells
title_sort novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079131/
https://www.ncbi.nlm.nih.gov/pubmed/35542771
http://dx.doi.org/10.1039/c8ra00271a
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