Cargando…
Multiple metals in children’s deciduous teeth: results from a community-initiated pilot study
BACKGROUND: Characterizing retrospective exposure to toxicants during multiple early-life developmental periods is challenging, yet critical for understanding developmental effects. OBJECTIVE: To characterize early-life metal exposure using deciduous teeth in a community concerned about past exposur...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079191/ https://www.ncbi.nlm.nih.gov/pubmed/34750512 http://dx.doi.org/10.1038/s41370-021-00400-x |
_version_ | 1784702508191449088 |
---|---|
author | Friedman, Alexa Bauer, Julia Anglen Austin, Christine Downs, Timothy J. Tripodis, Yorghos Heiger-Bernays, Wendy White, Roberta F. Arora, Manish Claus Henn, Birgit |
author_facet | Friedman, Alexa Bauer, Julia Anglen Austin, Christine Downs, Timothy J. Tripodis, Yorghos Heiger-Bernays, Wendy White, Roberta F. Arora, Manish Claus Henn, Birgit |
author_sort | Friedman, Alexa |
collection | PubMed |
description | BACKGROUND: Characterizing retrospective exposure to toxicants during multiple early-life developmental periods is challenging, yet critical for understanding developmental effects. OBJECTIVE: To characterize early-life metal exposure using deciduous teeth in a community concerned about past exposures. METHODS: Naturally shed teeth were collected from 30 children ages 5–13 years who resided in Holliston, Massachusetts since conception. We estimated weekly prenatal and postnatal (up to 1 year of age) exposure to 12 metals by measuring dentine concentrations using laser ablation-inductively coupled plasma-mass spectrometry. Multivariable linear mixed models were used to explore sociodemographic, dietary, and behavioral correlates of dentine metal concentrations. RESULTS: Temporal trends in dentine levels differed by metal. Source of milk during the first year of life was associated with dentine barium (Ba) levels, where being fed predominantly breastmilk was associated with 39% (95% CI: –57%, –13%) lower dentine Ba compared to predominantly formula use. Females had higher prenatal and postnatal dentine Mn and Pb, compared to males (e.g., % difference, postnatal Mn: 122% (17%, 321%); postnatal Pb: 60% (95% CI: –8%, 178%)). SIGNIFICANCE: Deciduous teeth provide retrospective information on dose and timing of early-life metals exposure at high resolution. We demonstrate their utility in a community-based study with known past contamination of drinking water. IMPACT STATEMENT: We conducted a community-initiated pilot study in a community concerned with historical exposure to multiple metals. Using deciduous teeth, a novel noninvasive biomarker, we characterized early-life exposure to 12 metals in approximately weekly increments during sensitive developmental periods, thus demonstrating the utility of this biomarker in communities concerned with past exposures. |
format | Online Article Text |
id | pubmed-9079191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-90791912022-05-21 Multiple metals in children’s deciduous teeth: results from a community-initiated pilot study Friedman, Alexa Bauer, Julia Anglen Austin, Christine Downs, Timothy J. Tripodis, Yorghos Heiger-Bernays, Wendy White, Roberta F. Arora, Manish Claus Henn, Birgit J Expo Sci Environ Epidemiol Article BACKGROUND: Characterizing retrospective exposure to toxicants during multiple early-life developmental periods is challenging, yet critical for understanding developmental effects. OBJECTIVE: To characterize early-life metal exposure using deciduous teeth in a community concerned about past exposures. METHODS: Naturally shed teeth were collected from 30 children ages 5–13 years who resided in Holliston, Massachusetts since conception. We estimated weekly prenatal and postnatal (up to 1 year of age) exposure to 12 metals by measuring dentine concentrations using laser ablation-inductively coupled plasma-mass spectrometry. Multivariable linear mixed models were used to explore sociodemographic, dietary, and behavioral correlates of dentine metal concentrations. RESULTS: Temporal trends in dentine levels differed by metal. Source of milk during the first year of life was associated with dentine barium (Ba) levels, where being fed predominantly breastmilk was associated with 39% (95% CI: –57%, –13%) lower dentine Ba compared to predominantly formula use. Females had higher prenatal and postnatal dentine Mn and Pb, compared to males (e.g., % difference, postnatal Mn: 122% (17%, 321%); postnatal Pb: 60% (95% CI: –8%, 178%)). SIGNIFICANCE: Deciduous teeth provide retrospective information on dose and timing of early-life metals exposure at high resolution. We demonstrate their utility in a community-based study with known past contamination of drinking water. IMPACT STATEMENT: We conducted a community-initiated pilot study in a community concerned with historical exposure to multiple metals. Using deciduous teeth, a novel noninvasive biomarker, we characterized early-life exposure to 12 metals in approximately weekly increments during sensitive developmental periods, thus demonstrating the utility of this biomarker in communities concerned with past exposures. Nature Publishing Group US 2021-11-08 2022 /pmc/articles/PMC9079191/ /pubmed/34750512 http://dx.doi.org/10.1038/s41370-021-00400-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Friedman, Alexa Bauer, Julia Anglen Austin, Christine Downs, Timothy J. Tripodis, Yorghos Heiger-Bernays, Wendy White, Roberta F. Arora, Manish Claus Henn, Birgit Multiple metals in children’s deciduous teeth: results from a community-initiated pilot study |
title | Multiple metals in children’s deciduous teeth: results from a community-initiated pilot study |
title_full | Multiple metals in children’s deciduous teeth: results from a community-initiated pilot study |
title_fullStr | Multiple metals in children’s deciduous teeth: results from a community-initiated pilot study |
title_full_unstemmed | Multiple metals in children’s deciduous teeth: results from a community-initiated pilot study |
title_short | Multiple metals in children’s deciduous teeth: results from a community-initiated pilot study |
title_sort | multiple metals in children’s deciduous teeth: results from a community-initiated pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079191/ https://www.ncbi.nlm.nih.gov/pubmed/34750512 http://dx.doi.org/10.1038/s41370-021-00400-x |
work_keys_str_mv | AT friedmanalexa multiplemetalsinchildrensdeciduousteethresultsfromacommunityinitiatedpilotstudy AT bauerjuliaanglen multiplemetalsinchildrensdeciduousteethresultsfromacommunityinitiatedpilotstudy AT austinchristine multiplemetalsinchildrensdeciduousteethresultsfromacommunityinitiatedpilotstudy AT downstimothyj multiplemetalsinchildrensdeciduousteethresultsfromacommunityinitiatedpilotstudy AT tripodisyorghos multiplemetalsinchildrensdeciduousteethresultsfromacommunityinitiatedpilotstudy AT heigerbernayswendy multiplemetalsinchildrensdeciduousteethresultsfromacommunityinitiatedpilotstudy AT whiterobertaf multiplemetalsinchildrensdeciduousteethresultsfromacommunityinitiatedpilotstudy AT aroramanish multiplemetalsinchildrensdeciduousteethresultsfromacommunityinitiatedpilotstudy AT claushennbirgit multiplemetalsinchildrensdeciduousteethresultsfromacommunityinitiatedpilotstudy |