A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement

We report an extremely rare case of extranodal B-cell NHL: DLBCL (diffuse large B-cell non-Hodgkin lymphoma), stage IVE, presenting with heart and bilateral adrenal involvement. On admission, adrenal and thorax imaging identified large bilateral adrenal masses and a 4.6 cm mass in the right atrium w...

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Autores principales: Papanastasiou, Labrini, Skarakis, Nikitas, Vardaka, Maria, Dimitriadi, Anastasia, Lampropoulou, Pinelopi, Perpinia, Anastasia, Vidalakis, Eleftherios, Choreftaki, Theodosia, Marinakis, Theodoros, Kounadi, Theodora, Vatalas, Ioannis-Anastasios, Michalis, Eurydiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079230/
https://www.ncbi.nlm.nih.gov/pubmed/35539018
http://dx.doi.org/10.1016/j.lrr.2022.100318
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author Papanastasiou, Labrini
Skarakis, Nikitas
Vardaka, Maria
Dimitriadi, Anastasia
Lampropoulou, Pinelopi
Perpinia, Anastasia
Vidalakis, Eleftherios
Choreftaki, Theodosia
Marinakis, Theodoros
Kounadi, Theodora
Vatalas, Ioannis-Anastasios
Michalis, Eurydiki
author_facet Papanastasiou, Labrini
Skarakis, Nikitas
Vardaka, Maria
Dimitriadi, Anastasia
Lampropoulou, Pinelopi
Perpinia, Anastasia
Vidalakis, Eleftherios
Choreftaki, Theodosia
Marinakis, Theodoros
Kounadi, Theodora
Vatalas, Ioannis-Anastasios
Michalis, Eurydiki
author_sort Papanastasiou, Labrini
collection PubMed
description We report an extremely rare case of extranodal B-cell NHL: DLBCL (diffuse large B-cell non-Hodgkin lymphoma), stage IVE, presenting with heart and bilateral adrenal involvement. On admission, adrenal and thorax imaging identified large bilateral adrenal masses and a 4.6 cm mass in the right atrium wall. An adrenal biopsy revealed the presence of a DLBCL, with triple expression of bcl2, bcl6, C-MYC(+70%). Following six cycles of systemic immunochemotherapy with R-DA-EPOCH, and high methotrexate dose for CNS prophylaxis a marked decrease of lymphoma infiltration was observed. The selection of the appropriate treatment modality can lead to profound response and improve patient's outcome.
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spelling pubmed-90792302022-05-09 A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement Papanastasiou, Labrini Skarakis, Nikitas Vardaka, Maria Dimitriadi, Anastasia Lampropoulou, Pinelopi Perpinia, Anastasia Vidalakis, Eleftherios Choreftaki, Theodosia Marinakis, Theodoros Kounadi, Theodora Vatalas, Ioannis-Anastasios Michalis, Eurydiki Leuk Res Rep Article We report an extremely rare case of extranodal B-cell NHL: DLBCL (diffuse large B-cell non-Hodgkin lymphoma), stage IVE, presenting with heart and bilateral adrenal involvement. On admission, adrenal and thorax imaging identified large bilateral adrenal masses and a 4.6 cm mass in the right atrium wall. An adrenal biopsy revealed the presence of a DLBCL, with triple expression of bcl2, bcl6, C-MYC(+70%). Following six cycles of systemic immunochemotherapy with R-DA-EPOCH, and high methotrexate dose for CNS prophylaxis a marked decrease of lymphoma infiltration was observed. The selection of the appropriate treatment modality can lead to profound response and improve patient's outcome. Elsevier 2022-04-27 /pmc/articles/PMC9079230/ /pubmed/35539018 http://dx.doi.org/10.1016/j.lrr.2022.100318 Text en © 2022 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Papanastasiou, Labrini
Skarakis, Nikitas
Vardaka, Maria
Dimitriadi, Anastasia
Lampropoulou, Pinelopi
Perpinia, Anastasia
Vidalakis, Eleftherios
Choreftaki, Theodosia
Marinakis, Theodoros
Kounadi, Theodora
Vatalas, Ioannis-Anastasios
Michalis, Eurydiki
A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement
title A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement
title_full A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement
title_fullStr A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement
title_full_unstemmed A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement
title_short A very rare case of extranodal B-cell non-Hodgkin lymphoma presenting with adrenal and heart involvement
title_sort very rare case of extranodal b-cell non-hodgkin lymphoma presenting with adrenal and heart involvement
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079230/
https://www.ncbi.nlm.nih.gov/pubmed/35539018
http://dx.doi.org/10.1016/j.lrr.2022.100318
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